ArticleAmerican journal of human genetics1999
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 3 of them syntheses that pooled it.
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Who cites it
68 citing papers in PubMed, 3 syntheses or guidelines pooled it, 262 citations in OpenAlex.
- Meta-Analysis on Associations of Alcohol Metabolism Genes With Alcohol Use Disorder in East Asians.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Pooled it
- Further clarification of the contribution of the ADH1C gene to vulnerability of alcoholism and selected liver diseases.Human genetics · 2012Pooled it
- Strong association of the alcohol dehydrogenase 1B gene (ADH1B) with alcohol dependence and alcohol-induced medical diseases.Biological psychiatry · 2011Pooled it
- CRISPR-Cas9 targeting of G-Quadruplex DNA in ADH1 promoter highlights its role in transcriptome and metabolome regulation.Nucleic acids research · 2025Article
- Assessing the association between ADH5 and ALDH1A1 genetic variants and substance use disorder risk in a Jordanian male population.BMC genomics · 2025Article
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- Genetic Variants of Alcohol Metabolizing Enzymes and Alcohol-Related Liver Cirrhosis Risk.Journal of personalized medicine · 2021Article
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- Candidate genes for predicting the survival of patients with gastric cancer: a study based on The Cancer Genome Atlas (TCGA) database.Translational cancer research · 2020Article
- Genetic, Psychological, and Personal Network Factors Associated With Changes in Binge Drinking Over 2 Years Among Mexican Heritage Adolescents in the USA.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019Article
- Alcohol Dehydrogenases, Aldehyde Dehydrogenases, and Alcohol Use Disorders: A Critical Review.Alcoholism, clinical and experimental research · 2018Review
- Recent Selection on a Class I ADH Locus Distinguishes Southwest Asian Populations Including Ashkenazi Jews.Genes · 2018Article
- The Analysis of Polymorphism of Alcohol Dehydrogenase 3 (ADH3) Gene and Influence of Liver Function Status in Indonesia.The Kobe journal of medical sciences · 2017Article
- Relationships of alcohol dehydrogenase 1B (ADH1B) and aldehyde dehydrogenase 2 (ALDH2) genotypes with alcohol sensitivity, drinking behavior and problem drinking in Japanese older men.Environmental health and preventive medicine · 2016Article
- ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men.Nagoya journal of medical science · 2016Article
- Interactions Between Alcohol Metabolism Genes and Religious Involvement in Association With Maximum Drinks and Alcohol Dependence Symptoms.Journal of studies on alcohol and drugs · 2016Article
- Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer.Oncology letters · 2016Article
- Under-Researched Demographics: Heavy Episodic Drinking and Alcohol-Related Problems Among Asian Americans.Alcohol research : current reviews · 2016Review
- Article
- Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.Alcohol research : current reviews · 2016Review
8 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
Two of the three class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode known functional variants that act on alcohol with different efficiencies. Variants at both these genes have been implicated in alcoholism in some populations because allele frequencies differ between alcoholics and controls. Specifically, controls have higher frequencies of the variants with higher Vmax (ADH2*2 and ADH3*1). In samples both of alcoholics and of controls from three Taiwanese populations (Chinese, Ami, and Atayal) we found significant pairwise disequilibrium for all comparisons of the two functional polymorphisms and a third, presumably neutral, intronic polymorphism in ADH2. The class I ADH genes all lie within 80 kb on chromosome 4; thus, variants are not inherited independently, and haplotypes must be analyzed when evaluating the risk of alcoholism. In the Taiwanese Chinese we found that, only among those chromosomes containing the ADH3*1 variant (high Vmax), the proportions of chromosomes with ADH2*1 (low Vmax) and those with ADH2*2 (high Vmax) are significantly different between alcoholics and controls (P<10-5). The proportions of chromosomes with ADH3*1 and those with ADH3*2 are not significantly different between alcoholics and controls, on a constant ADH2 background (with ADH2*1, P=.83; with ADH2*2, P=.53). Thus, the observed differences in the frequency of the functional polymorphism at ADH3, between alcoholics and controls, can be accounted for by the disequilibrium with ADH2 in this population.
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