ArticleGenes & development1999
Uncoupling integrin adhesion and signaling: the betaPS cytoplasmic domain is sufficient to regulate gene expression in the Drosophila embryo.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 80 citations in OpenAlex.
- A dystroglycan-laminin-integrin axis coordinates cell shape remodeling in the developing Drosophila retina.PLoS biology · 2024Article
- Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues.eLife · 2023Article
- Reciprocal discoidin domain receptor signaling strengthens integrin adhesion to connect adjacent tissues.bioRxiv : the preprint server for biology · 2023Article
- Importance of clitellar tissue in the regeneration ability of earthworm Eudrilus eugeniae.Functional & integrative genomics · 2022Article
- Multifaceted control of E-cadherin dynamics by Adaptor Protein Complex 1 during epithelial morphogenesis.Molecular biology of the cell · 2022Article
- Epithelial Cell Polarity DuringFrontiers in cell and developmental biology · 2022Review
- Integrins Cooperate With the EGFR/Ras Pathway to Preserve Epithelia Survival and Architecture in Development and Oncogenesis.Frontiers in cell and developmental biology · 2022Article
- Article
- Genes and pathways associated with pregnancy loss in dairy cattle.Scientific reports · 2021Article
- Article
- Integrins are required for synchronous ommatidial rotation in the Drosophila eye linking planar cell polarity signalling to the extracellular matrix.Open biology · 2019Article
- TheThe Journal of biological chemistry · 2019Article
- Polarization of Myosin II Refines Tissue Material Properties to Buffer Mechanical Stress.Developmental cell · 2019Article
- Integrin signaling downregulates filopodia during muscle-tendon attachment.Journal of cell science · 2018Article
- Peak BMP Responses in the Drosophila Embryo Are Dependent on the Activation of Integrin Signaling.Cell reports · 2015Article
- The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins.The EMBO journal · 2014Article
- Integrins regulate epithelial cell differentiation by modulating Notch activity.Journal of cell science · 2014Article
- A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration.Journal of cell science · 2013Article
- The Par complex and integrins direct asymmetric cell division in adult intestinal stem cells.Cell stem cell · 2012Article
- Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates.Cold Spring Harbor perspectives in biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Integrin cell surface receptors are ideally suited to coordinate cellular differentiation and tissue assembly during embryogenesis, as they can mediate both signaling and adhesion. We show that integrins regulate gene expression in the intact developing embryo by identifying two genes that require integrin function for their normal expression in Drosophila midgut endodermal cells. We determined the relative roles of integrin adhesion versus signaling in the regulation of these integrin target genes. We find that integrin-mediated adhesion is not required between the endodermal cells and the surrounding visceral mesoderm for integrin target gene expression. In addition, a chimeric protein that lacks integrin-adhesive function, but maintains the ability to signal, can substitute for the endogenous integrin and regulate integrin target genes. This chimera consists of an oligomeric extracellular domain fused to the integrin betaPS subunit cytoplasmic domain; a control monomeric extracellular domain fusion does not alter integrin target gene expression. Therefore, oligomerization of the 47-amino-acid betaPS intracellular domain is sufficient to initiate a signaling pathway that regulates gene expression in the developing embryo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.