Trial reportArchives of surgery (Chicago, Ill. : 1960)1999
Insulin's anabolic effect is influenced by route of administration of nutrients.
Trial report in Archives of surgery (Chicago, Ill. : 1960), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 9 citations in OpenAlex.
- Nutrition in the intensive care unit.Critical care (London, England) · 1999Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine if the anabolic effects of intravenous insulin on protein kinetics could be exploited in the enterally fed trauma victim.
designRandomized, crossover control protocol.
settingLevel I trauma center. PATIENTS: Ten trauma patients with an Injury Severity Score higher than 20. Exclusion criteria included diabetes mellitus, pregnancy, steroid use, and aged younger than 18 years or older than 65 years.
interventionsWithin the first 24 hours of admission to the intensive care unit, each patient had a transpyloric feeding tube inserted radiographically. Enteral nutrition was provided with a protein supplement (Ensure, Ross Laboratories, Columbus, Ohio) and Promod, supplemented with protein powder to supply 1.5 g/kg per day of protein and 156.9 kJ/kg per day. Intravenous insulin was provided at 0.043 U/kg per hour beginning on the second or fourth day.
main outcome measuresUrinary nitrogen balance and 3-methylhistidine excretion rates were measured at the end of the third and fifth days. Plasma glucose, insulin, and C-peptide levels were obtained at these same times.
resultsUrinary nitrogen balance was not significantly different with or without the administration of insulin (-4.58+/-50.1 mg/kg per day vs -9.38+/-50.9 mg/kg per day, respectively). 3-Methylhistidine excretion rates did not change significantly with or without the administration of insulin (5.77+/-0.67 micromol/kg per day vs 6.15+/-0.43 micromol/kg per day, respectively). Serum insulin levels did not differ significantly when exogenous infusions were added (57.8+/-17.9 microU/mL vs 82.1+/-44.9 microU/mL), but serum C-peptide levels did decrease significantly when exogenous insulin was added (5.11+/-3.2 microU/mL vs 10.28+/-3.5 microU/mL; P = .04). Serum glucose levels decreased significantly when insulin was administered (5.8+/-0.4 mmol/L [104.6+/-7.2 mg/dL] vs 7.7+/-0.4 mmol/L [138.1+/-7.4 mg/dL; P =.004).
conclusionThe anabolic effect of intravenous insulin on protein kinetics is not evident when nutrition is provided enterally in the trauma victim.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.