ArticleThe Journal of physiology1999
Quantal size is correlated with receptor cluster area at glycinergic synapses in the rat brainstem.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 82 citations in OpenAlex.
- GABA corelease guides the functional maturation of glycinergic synapses in an auditory sound localization circuit.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- TREK1 Channels Shape Spindle-Like Oscillations, Neuronal Activity, and Short-Term Synaptic Plasticity in Thalamocortical Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Light microscopy based approach for mapping connectivity with molecular specificity.Nature communications · 2020Article
- Alfaxalone Causes Reduction of Glycinergic IPSCs, but Not Glutamatergic EPSCs, and Activates a Depolarizing Current in Rat Hypoglossal Motor Neurons.Frontiers in cellular neuroscience · 2019Article
- Combining mGRASP and Optogenetics Enables High-Resolution Functional Mapping of Descending Cortical Projections.Cell reports · 2018Article
- Developmental Shift of Inhibitory Transmitter Content at a Central Auditory Synapse.Frontiers in cellular neuroscience · 2017Article
- Article
- Dynamic fidelity control to the central auditory system: synergistic glycine/GABAergic inhibition in the cochlear nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Differential distribution of glycine receptor subtypes at the rat calyx of Held synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Lateral superior olive function in congenital deafness.Hearing research · 2011Article
- Synaptic changes underlying the strengthening of GABA/glycinergic connections in the developing lateral superior olive.Neuroscience · 2010Article
- Quantal analysis reveals a functional correlation between presynaptic and postsynaptic efficacy in excitatory connections from rat neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Early history of glycine receptor biology in Mammalian spinal cord circuits.Frontiers in molecular neuroscience · 2010Article
- Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons.Molecular pain · 2009Article
- Inflammation regulates functional integration of neurons born in adult brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Numbers, densities, and colocalization of AMPA- and NMDA-type glutamate receptors at individual synapses in the superficial spinal dorsal horn of rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Noise in the nervous system.Nature reviews. Neuroscience · 2008Review
- The continuing case for the Renshaw cell.The Journal of physiology · 2007Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
1. Whole-cell patch electrode recordings of glycinergic miniature inhibitory postsynaptic currents (mIPSCs) were obtained in neurons of the rat anteroventral cochlear nucleus (AVCN). Mean mIPSC peak amplitude was found to vary considerably between AVCN neurons (range, -19.1 to -317.9 pA; mean +/- s.d., -159.1 +/- 100.7 pA; 14 cells). 2. Immunolabelling of glycinergic receptor clusters in AVCN neurons was performed using antibodies against the glycine receptor clustering protein gephyrin. Measurements of the area of gephyrin immunoreactive clusters were obtained using confocal fluorescence microscopy. These measurements showed a large variability in cluster area, not only in the same cell (mean coefficient of variation, c.v., 0.66 +/- 0.18; 16 cells), but also in mean cluster area between cells (range, 0.21-0.84 microm2; 16 cells). 3. A possible relationship between mIPSC amplitude and receptor cluster area was investigated in a further series of experiments, in which mIPSCs recordings and immunolabelling of glycine receptor clusters were obtained for the same cells. In these experiments, AVCN neurons were identified using intracellular labelling with neurobiotin. Successful results using a combination of whole-cell recordings, neurobiotin identification and immunolabelling were obtained for a total of 10 AVCN neurons. Analysis of the results revealed a positive, statistically significant correlation between mean receptor cluster size and mean mIPSC amplitude (P < 0.05, 10 cells, Spearman's correlation test). 4. These results provide direct experimental evidence supporting a hypothesis of central glycinergic transmission in which synaptic strength may be regulated by changes in the size of the postsynaptic receptor region.
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