ArticleThe Journal of physiology1999
Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 66 citations in OpenAlex.
- Cardio-Oncology in Cold Climates: Epidemiological Features, Bidirectional Interaction Mechanisms, and Integrated Management Strategies.Cardiovascular toxicology · 2026Review
- Cancer Chemotherapy-Induced Sinus Bradycardia: A Narrative Review of a Forgotten Adverse Effect of Cardiotoxicity.Drug safety · 2022Review
- What Causes Death in Esophageal Cancer Patients Other Than the Cancer Itself: A Large Population-Based Analysis.Journal of Cancer · 2022Article
- Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice.Developmental cell · 2021Article
- Development and progression of cancer cachexia: Perspectives from bench to bedside.Sports medicine and health science · 2020Article
- Mechanobiology Assays with Applications in Cardiomyocyte Biology and Cardiotoxicity.Advanced healthcare materials · 2020Review
- Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies.American journal of physiology. Cell physiology · 2019Article
- Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol.International journal of oncology · 2018Article
- Pharmacogenetics of Chemotherapy-Induced Cardiotoxicity.Current oncology reports · 2018Review
- Chemotherapeutic Agents and the Risk of Ischemia and Arterial Thrombosis.Current atherosclerosis reports · 2018Review
- Out of the frying pan and into the fire: damage-associated molecular patterns and cardiovascular toxicity following cancer therapy.Therapeutic advances in cardiovascular disease · 2017Review
- Dapagliflozin reduces the amplitude of shortening and Ca(2+) transient in ventricular myocytes from streptozotocin-induced diabetic rats.Molecular and cellular biochemistry · 2015Article
- THE INHIBITORY EFFECT OF PACLITAXEL ON (Kv2.1) K+ CURRENT IN H9c2 CELLS.Fukushima journal of medical science · 2015Article
- Contractility of ventricular myocytes is well preserved despite altered mechanisms of Ca2+ transport and a changing pattern of mRNA in aged type 2 Zucker diabetic fatty rat heart.Molecular and cellular biochemistry · 2012Article
- Mechanical modulation of cardiac microtubules.Pflugers Archiv : European journal of physiology · 2011Review
- Taxol, a microtubule stabilizer, prevents ischemic ventricular arrhythmias in rats.Journal of cellular and molecular medicine · 2011Article
- Sodium channel traffic on the cardiac microtubule highway.Cardiovascular research · 2010Article
- Stable microtubules contribute to cardiac dysfunction in the streptozotocin-induced model of type 1 diabetes in the rat.Molecular and cellular biochemistry · 2007Article
- Halothane alters contractility and Ca2+ transport in ventricular myocytes from streptozotocin-induced diabetic rats.Molecular and cellular biochemistry · 2004Article
- Voltage-dependence of contraction in streptozotocin-induced diabetic myocytes.Molecular and cellular biochemistry · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Microtubules form part of the cytoskeleton. Their role in adult ventricular myocytes is not well understood although microtubule proliferation has previously been linked with reduced contractile function. 2. We investigated the effect of the anti-tumour drug taxol, a known microtubule polymerizing agent, on Ca2+ handling in adult rat ventricular myocytes. 3. Treatment of cells with taxol caused proliferation of microtubules. 4. In taxol-treated cells there was a reduction in the amplitude of contraction, no significant effect on the amplitude of L-type Ca2+ current, but a significant reduction in the amplitude of the Ca2+ transient. 5. Caffeine was used to release Ca2+ from the sarcoplasmic reticulum (SR). There was a significant reduction in the ratio of electrically stimulated : caffeine-induced Ca2+ transients in taxol-treated cells. This observation is consistent with the hypothesis that taxol reduces fractional SR Ca2+ release. 6. We suggest that the negative inotropic effect of taxol may, at least in part, be the result of reduced release of Ca2+ from the SR. Microtubules may be important regulators of Ca2+ handling in the heart.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.