ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
A neurocomputational theory of the dopaminergic modulation of working memory functions.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 232 citations in OpenAlex.
- Enhanced switching and familial susceptibility for psychosis.Brain and behavior · 2018Trial
- Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers.Psychopharmacology · 2004Trial
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- Amphetamine reduces reward encoding and stabilizes neural dynamics in rat anterior cingulate cortex.eLife · 2020Article
- Neural Substrates of Inhibitory Control Maturation in Adolescence.Trends in neurosciences · 2019Review
- Prefronto-cortical dopamine D1 receptor sensitivity can critically influence working memory maintenance during delayed response tasks.PloS one · 2018Article
- Is the Capacity for Vocal Learning in Vertebrates Rooted in Fish Schooling Behavior?Evolutionary biology · 2018Review
- Temporal Dynamics of Hippocampal and Medial Prefrontal Cortex Interactions During the Delay Period of a Working Memory-Guided Foraging Task.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- A state space approach for piecewise-linear recurrent neural networks for identifying computational dynamics from neural measurements.PLoS computational biology · 2017Article
- Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition.Schizophrenia research · 2017Article
- Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion.PLoS biology · 2016Article
- Amphetamine Exerts Dose-Dependent Changes in Prefrontal Cortex Attractor Dynamics during Working Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Bridging Levels of Understanding in Schizophrenia Through Computational Modeling.Clinical psychological science : a journal of the Association for Psychological Science · 2015Article
- Dopaminergic modulation of distracter-resistance and prefrontal delay period signal.Psychopharmacology · 2015Article
- Stochastic Mesocortical Dynamics and Robustness of Working Memory during Delay-Period.PloS one · 2015Article
- Long-term memory and the control of attentional control.Cognitive psychology · 2014Article
- Balanced cortical microcircuitry for spatial working memory based on corrective feedback control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Self-generated sounds of locomotion and ventilation and the evolution of human rhythmic abilities.Animal cognition · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dopaminergic modulation of neural activity in the prefrontal cortex (PFC) is essential for working memory. Delay-activity in the PFC in working memory tasks persists even if interfering stimuli intervene between the presentation of the sample and the target stimulus. Here, the hypothesis is put forward that the functional role of dopamine in working memory processing is to stabilize active neural representations in the PFC network and thereby to protect goal-related delay-activity against interfering stimuli. To test this hypothesis, we examined the reported dopamine-induced changes in several biophysical properties of PFC neurons to determine whether they could fulfill this function. An attractor network model consisting of model neurons was devised in which the empirically observed effects of dopamine on synaptic and voltage-gated membrane conductances could be represented in a biophysically realistic manner. In the model, the dopamine-induced enhancement of the persistent Na+ and reduction of the slowly inactivating K+ current increased firing of the delay-active neurons, thereby increasing inhibitory feedback and thus reducing activity of the "background" neurons. Furthermore, the dopamine-induced reduction of EPSP sizes and a dendritic Ca2+ current diminished the impact of intervening stimuli on current network activity. In this manner, dopaminergic effects indeed acted to stabilize current delay-activity. Working memory deficits observed after supranormal D1-receptor stimulation could also be explained within this framework. Thus, the model offers a mechanistic explanation for the behavioral deficits observed after blockade or after supranormal stimulation of dopamine receptors in the PFC and, in addition, makes some specific empirical predictions.
Indexed as
Identifiers
10087092PMC6786084W2168590813What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.