ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Noninvasive measurements of the membrane potential and GABAergic action in hippocampal interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The trial behind it
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Who cites it
73 citing papers in PubMed, 134 citations in OpenAlex.
- Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination.Experimental & molecular medicine · 2026Article
- A novel and evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.Research square · 2025Article
- A novel, evolutionarily conserved inhibitory circuit selectively regulates dentate gyrus mossy cell function.bioRxiv : the preprint server for biology · 2025Article
- Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.Neuron · 2025Article
- Divergent opioid-mediated suppression of inhibition between hippocampus and neocortex across species and development.bioRxiv : the preprint server for biology · 2025Article
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Evidence for Two Subpopulations of Cerebrospinal Fluid-Contacting Neurons with Opposite GABAergic Signaling in Adult Mouse Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Optogenetic Determination of Dynamic and Cell-Type-Specific Inhibitory Reversal Potentials.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Bidirectional Regulation of GABALife (Basel, Switzerland) · 2024Review
- A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations.iScience · 2023Article
- Candelabrum cells are ubiquitous cerebellar cortex interneurons with specialized circuit properties.Nature neuroscience · 2022Article
- On the accuracy of cell-attached current-clamp recordings from cortical neurons.Frontiers in molecular neuroscience · 2022Article
- Measuring Absolute Membrane Potential Across Space and Time.Annual review of biophysics · 2021Review
- Histone Deacetylase Inhibitor Improves the Dysfunction of Hippocampal Gamma Oscillations and Fast Spiking Interneurons in Alzheimer's Disease Model Mice.Frontiers in molecular neuroscience · 2021Article
- Article
- Estradiol Enhances the Depolarizing Response to GABA and AMPA Synaptic Conductances in Arcuate Kisspeptin Neurons by Diminishing Voltage-Gated Potassium Currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- KCC2-Mediated ClCell reports · 2019Article
- Prepubertal Development of GABAergic Transmission to Gonadotropin-Releasing Hormone (GnRH) Neurons and Postsynaptic Response Are Altered by Prenatal Androgenization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Gonadotropin-Releasing Hormone (GnRH) Neuron Excitability Is Regulated by Estradiol Feedback and Kisspeptin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Emergence of Relaxation Oscillations in Neurons Interacting With Non-stationary Ambient GABA.Frontiers in computational neuroscience · 2018Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Neurotransmitters affect the membrane potential (Vm) of target cells by modulating the activity of receptor-linked ion channels. The direction and amplitude of the resulting transmembrane current depend on the resting level of Vm and the gradient across the membrane of permeant ion species. Vm, in addition, governs the activation state of voltage-gated channels. Knowledge of the exact level of Vm is therefore crucial to evaluate the nature of the neurotransmitter effect. However, the traditional methods to measure Vm, with microelectrodes or the whole-cell current-clamp technique, have the drawback that the recording pipette is in contact with the cytoplasm, and dialysis with the pipette solution alters the ionic composition of the interior of the cell. Here we describe a novel technique to determine the Vm of an intact cell from the reversal potential of K+ currents through a cell-attached patch. Applying the method to interneurons in hippocampal brain slices yielded more negative values for Vm than subsequent whole-cell current-clamp measurements from the same cell, presumably reflecting the development of a Donnan potential between cytoplasm and pipette solution in the whole-cell mode. Cell-attached Vm measurements were used to study GABAergic actions in intact CA1 interneurons. In 1- to 3-week-old rats, bath-applied GABA inhibited these cells by stabilizing Vm at a level depending on contributions from both GABAA and GABAB components. In contrast, in 1- to 4-d-old animals, only GABAA receptors were activated resulting in a depolarizing GABA response.
Indexed as
Identifiers
10087068PMC6786065W1494945459What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.