Trial reportArchives of disease in childhood1999
Randomised controlled trial of budesonide for the prevention of post-bronchiolitis wheezing.
Trial report in Archives of disease in childhood, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Antibiotics for persistent cough or wheeze following acute bronchiolitis in children.The Cochrane database of systematic reviews · 2017Pooled it
- Glucocorticoids for acute viral bronchiolitis in infants and young children.The Cochrane database of systematic reviews · 2013Pooled it
- Inhaled corticosteroids for subacute cough in children.The Cochrane database of systematic reviews · 2013Pooled it
- Clinical review: a systematic review of corticosteroid use in infections.Critical care (London, England) · 2006Pooled it
- The effect of high dose inhaled corticosteroids on wheeze in infants after respiratory syncytial virus infection: randomised double blind placebo controlled trial.BMJ (Clinical research ed.) · 2009Trial
- Persistent wheezing in infants with an atopic tendency responds to inhaled fluticasone.Archives of disease in childhood · 2001Trial
- Azithromycin administered for acute bronchiolitis may have a protective effect on subsequent wheezing.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaTrial
- Article
- The Effects of Inhaled Steroids on Recurrent Wheeze After Acute Bronchiolitis: A Systematic Review and Meta-Analysis of 748 Patients.Global pediatric health · 2015Article
- Effects of systemic versus local administration of corticosteroids on mucosal tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Effects of titanium dioxide nanoparticle exposure on neuroimmune responses in rat airways.Journal of toxicology and environmental health. Part A · 2010Article
- Management of paediatric asthma.Postgraduate medical journal · 2004Review
- Management of unresponsive asthma.Indian journal of pediatrics · 2004Review
- Difficult asthma in children.Thorax · 2002Review
- Prevention and treatment of respiratory syncytial virus bronchiolitis and postbronchiolitic wheezing.Respiratory research · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies suggest that recurrent episodes of coughing and wheezing occur in up to 75% of infants after acute viral bronchiolitis.
aimTo assess the efficacy of budesonide given by means of a metered dose inhaler, spacer, and face mask in reducing the incidence of coughing and wheezing episodes up to 12 months after acute viral bronchiolitis.
methodsChildren under the age of 12 months admitted to hospital with acute viral bronchiolitis were randomised to receive either budesonide or placebo (200 microg or one puff twice daily) for the next eight weeks. Parents kept a diary card record of all episodes of coughing and wheezing over the next 12 months.
resultsFull follow up data were collected for 49 infants. There were no significant differences between the two study groups for the number of infants with symptom episodes up to six months after hospital discharge. At 12 months, 21 infants in the budesonide group had symptom episodes compared with 12 of 24 in the placebo group. The median number of symptom episodes was 2 (range, 0-13) in those who received budesonide and 1 (range, 0-11) in those who received placebo. Because there is no pharmacological explanation for these results, they are likely to be caused by a type 1 error, possibly exacerbated by there being more boys in the treatment group.
conclusionRoutine administration of budesonide by means of a metered dose inhaler, spacer, and face mask system immediately after acute viral bronchiolitis cannot be recommended.
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