ArticleInfection and immunity1999
CD40 ligation prevents Trypanosoma cruzi infection through interleukin-12 upregulation.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- T cells responding to Trypanosoma cruzi detected by membrane TNF-α and CD154 in chagasic patients.Immunity, inflammation and disease · 2018Trial
- Review
- Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model.PLoS pathogens · 2016Article
- Trypanosoma cruzi infection induces the expression of CD40 in murine cardiomyocytes favoring CD40 ligation-dependent production of cardiopathogenic IL-6.Parasitology research · 2016Article
- CD40 is required for protective immunity against liver stage Plasmodium infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Induction of IL-12 production in human peripheral monocytes by Trypanosoma cruzi Is mediated by glycosylphosphatidylinositol-anchored mucin-like glycoproteins and potentiated by IFN- γ and CD40-CD40L interactions.Mediators of inflammation · 2014Article
- CD40 and tumour necrosis factor-α co-operate to up-regulate inducuble nitric oxide synthase expression in macrophages.Immunology · 2012Article
- Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung.The American journal of pathology · 2010Article
- CD40 and the immune response to parasitic infections.Seminars in immunology · 2009Review
- Article
- Nitric oxide contributes to host resistance against experimental Taenia crassiceps cysticercosis.Parasitology research · 2007Article
- CD40-CD40L interaction in immunity against protozoan infections.Journal of biomedicine & biotechnology · 2007Article
- Transfection of Trypanosoma cruzi with host CD40 ligand results in improved control of parasite infection.Infection and immunity · 2005Article
- CD40-CD154 interactions between macrophages and natural killer cells during sepsis are critical for macrophage activation and are not interferon gamma dependent.Clinical and experimental immunology · 2004Article
- CD40 contributes to lethality in acute sepsis: in vivo role for CD40 in innate immunity.Infection and immunity · 2003Article
- Roles for CD40, B7 and major histocompatibility complex in induction of enhanced immunity by cryptococcal polysaccharide-pulsed antigen-presenting cells.Immunology · 2003Article
- Systemic treatment with anti-CD40 antibody stimulates Langerhans cell migration from the skin.Clinical and experimental immunology · 2002Article
- Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Because of the critical role of the CD40-CD40 ligand (CD40L) pathway in the induction and effector phases of immune responses, we investigated the effects of CD40 ligation on the control of Trypanosoma cruzi infection. First, we observed that supernatants of murine spleen cells stimulated by CD40L-transfected 3T3 fibroblasts (3T3-CD40L transfectants) prevent the infection of mouse peritoneal macrophages (MPM) by T. cruzi. This phenomenon depends on de novo production of nitric oxide (NO) as it is prevented by the addition of N-nitro-L-arginine methyl ester, a NO synthase inhibitor. NO production requires interleukin (IL)-12-mediated gamma interferon (IFN-gamma) and tumor necrosis factor alpha (TNF-alpha) synthesis as demonstrated by inhibition experiments using neutralizing anti-IL-12, anti-IFN-gamma, and anti-TNF-alpha monoclonal antibodies (MAb). We found that an activating anti-CD40 MAb also directly stimulates IFN-gamma-activated MPM to produce NO and thereby to control T. cruzi infection. To determine the in vivo relevance of these in vitro findings, mice were injected with 3T3-CD40L transfectants or 3T3 control fibroblasts at the time of T. cruzi inoculation. We observed that in vivo CD40 ligation dramatically reduced both parasitemia and the mortality rate of T. cruzi-infected mice. A reduced parasitemia was still observed when the injection of 3T3-CD40L transfectants was delayed 8 days postinfection. It was abolished by injection of anti-IL-12 MAb. Taken together, these data establish that CD40 ligation facilitates the control of T. cruzi infection through a cascade involving IL-12, IFN-gamma, and NO.
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