ArticleInfection and immunity1999
Immune response to Yersinia outer proteins and other Yersinia pestis antigens after experimental plague infection in mice.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 86 citations in OpenAlex.
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- The Use of an Organo-Selenium Peptide to Develop New Antimicrobials That Target a Specific Bacteria.Antibiotics (Basel, Switzerland) · 2021Article
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- New Promising Targets for Synthetic Omptin-Based Peptide Vaccine against Gram-Negative Pathogens.Vaccines · 2019Article
- A Combined YopB and LcrV Subunit Vaccine Elicits Protective Immunity againstJournal of immunology (Baltimore, Md. : 1950) · 2019Article
- Humoral and cellular immune responses to Yersinia pestis Pla antigen in humans immunized with live plague vaccine.PLoS neglected tropical diseases · 2018Article
- A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates.Clinical and vaccine immunology : CVI · 2016Article
- Expression and Association of the Yersinia pestis Translocon Proteins, YopB and YopD, Are Facilitated by Nanolipoprotein Particles.PloS one · 2016Article
- Plague Vaccines: Status and Future.Advances in experimental medicine and biology · 2016Review
- Protecting against plague: towards a next-generation vaccine.Clinical and experimental immunology · 2013Review
- LcrV mutants that abolish Yersinia type III injectisome function.Journal of bacteriology · 2013Article
- A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with Yersinia pestis.Innate immunity · 2012Article
- Humoral and cellular immune responses to Yersinia pestis infection in long-term recovered plague patients.Clinical and vaccine immunology : CVI · 2012Article
- Immune responses to plague infection in wild Rattus rattus, in Madagascar: a role in foci persistence?PloS one · 2012Article
- Efficacy and safety of a modified vaccinia Ankara (MVA) vectored plague vaccine in mice.Vaccine · 2010Article
- Protection against pneumonic plague following oral immunization with a non-replicating vaccine.Vaccine · 2010Article
- The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection.Infection and immunity · 2010Article
- High-throughput identification of new protective antigens from a Yersinia pestis live vaccine by enzyme-linked immunospot assay.Infection and immunity · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is limited information concerning the nature and extent of the immune response to the virulence determinants of Yersinia pestis during the course of plague infection. In this study, we evaluated the humoral immune response of mice that survived lethal Y. pestis aerosol challenge after antibiotic treatment. Such a model may replicate the clinical situation in humans and indicate which virulence determinants are expressed in vivo. Immunoglobulin G enzyme-linked immunosorbent assay and immunoblotting were performed by using purified, recombinant antigens including F1, V antigen, YpkA, YopH, YopM, YopB, YopD, YopN, YopE, YopK, plasminogen activator protease (Pla), and pH 6 antigen as well as purified lipopolysaccharide. The major antigens recognized by murine convalescent sera were F1, V antigen, YopH, YopM, YopD, and Pla. Early treatment with antibiotics tended to reduce the immune response and differences between antibiotic treatment regimens were noted. These results may indicate that only some virulence factors are expressed and/or immunogenic during infection. This information may prove useful for selecting potential vaccine candidates and for developing improved serologic diagnostic assays.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.