ArticleInfection and immunity1999
Identification and characterization of the cps locus of Streptococcus suis serotype 2: the capsule protects against phagocytosis and is an important virulence factor.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers, 1 of them a synthesis that pooled it.
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Who cites it
200 citing papers in PubMed, 1 synthesis or guideline pooled it, 385 citations in OpenAlex.
- Identification ofVirulence · 2021Pooled it
- Innate immune response to Streptococcus suis infection: advances and future challenges.Veterinary research · 2026Review
- Developing a cps-genotyping scheme for the emerging zoonotic pathogen Streptococcus parasuis through genetic analysis of capsular polysaccharide synthesis gene loci.BMC microbiology · 2026Article
- Article
- A conserved glycan motif induces broadly reactive functional antibodies against the zoonotic pathogenScience advances · 2026Article
- Maternal antibodies against the immunoglobulin M-degrading enzyme of Streptococcus suis, IdeVeterinary research · 2026Article
- Genomic analysis of a clinical Streptococcus suis ST1 isolate from CSF reveals antimicrobial resistance, virulence, and an evolutionary link to ST7.Scientific reports · 2026Article
- Streptococcus suis avian expansion suggests shared antibiotic use drives host jumps.BMC biology · 2025Article
- Tyrosine kinase Cps2C regulates the synthesis of capsular polysaccharides and plays a role in the virulence ofVirulence · 2025Article
- A new lymph node infection model for Streptococcus suis serotype 2 in pigs.Veterinary research · 2025Article
- Article
- Identification of the methionine transporter MetQ in Streptococcus suis and its contribution to virulence and biofilm formation.Veterinary research · 2025Article
- Identification and characterization of ugpE associated with the full virulence of Streptococcus suis.Veterinary research · 2025Article
- Investigation of genomic and pathogenicity characteristics ofEmerging microbes & infections · 2024Article
- Variation in bacterial pathotype is consistent with the sit-and-wait hypothesis.Microbiology (Reading, England) · 2024Article
- Whole genome sequence and characterisation of Streptococcus suis 3112, isolated from snakeskin gourami, Trichopodus pectoralis.BMC genomics · 2024Article
- Identification and genomic analyses of aHeliyon · 2024Article
- Identification and genetic engineering of pneumococcal capsule-like polysaccharides in commensal oral streptococci.Microbiology spectrum · 2024Article
- AVaccines · 2024Article
- Characterization of pig tonsils as niches for the generation of Streptococcus suis diversity.Veterinary research · 2024Article
140 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To study the role of the capsule of Streptococcus suis serotype 2 in virulence, we generated two isogenic mutants disturbed in capsule production. For that purpose, we first cloned and characterized a major part of the capsular polysaccharide biosynthesis (cps) locus of S. suis serotype 2. Based on the established sequence, 14 open reading frames (ORFs), designated Orf2Z, Orf2Y, Orf2X, and Cps2A to Cps2K, were identified. Twelve ORFs belonged to a single transcriptional unit. The gene products of 11 of these ORFs showed similarity to proteins involved in polysaccharide biosynthesis of other gram-positive microorganisms. Nonencapsulated isogenic mutants were generated in the cps2B and cps2EF genes by insertional mutagenesis. In contrast to the wild-type S. suis serotype 2 strain, the nonencapsulated strains were highly sensitive to ingestion by porcine alveolar lung macrophages in vitro. More importantly, the nonencapsulated mutant strains were completely avirulent in young germfree pigs after intranasal inoculation. These observations indicate that the capsule of S. suis serotype 2 plays an essential role in the pathogenesis of S. suis serotype 2 infections.
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