ArticleInfection and immunity1999
Protein H, an antiphagocytic surface protein in Streptococcus pyogenes.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Molecular mechanism of complement interference by Streptococcus pyogenes nuclease A.Communications biology · 2026Article
- Superantigen Recognition and Interactions: Functions, Mechanisms and Applications.Frontiers in immunology · 2021Review
- A Predictive Model of Antibody Binding in the Presence of IgG-Interacting Bacterial Surface Proteins.Frontiers in immunology · 2021Article
- Hijacking Factor H for Complement Immune Evasion.Frontiers in immunology · 2021Review
- Human IgG Increases Virulence ofJournal of immunology (Baltimore, Md. : 1950) · 2018Article
- Factor H-IgG Chimeric Proteins as a Therapeutic Approach against the Gram-Positive Bacterial PathogenJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Virulence of Group A Streptococci Is Enhanced by Human Complement Inhibitors.PLoS pathogens · 2015Article
- Resistance of Neisseria meningitidis to human serum depends on T and B cell stimulating protein B.Infection and immunity · 2015Article
- The AgI/II family adhesin AspA is required for respiratory infection by Streptococcus pyogenes.PloS one · 2013Article
- Collagen VI encodes antimicrobial activity: novel innate host defense properties of the extracellular matrix.Journal of innate immunity · 2012Article
- Binding of the human complement regulators CFHR1 and factor H by streptococcal collagen-like protein 1 (Scl1) via their conserved C termini allows control of the complement cascade at multiple levels.The Journal of biological chemistry · 2010Article
- Streptococcus adherence and colonization.Microbiology and molecular biology reviews : MMBR · 2009Review
- Impact of the SpeB protease on binding of the complement regulatory proteins factor H and factor H-like protein 1 by Streptococcus pyogenes.Infection and immunity · 2005Article
- Recombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses.Infection and immunity · 2004Article
- Recruitment of complement factor H-like protein 1 promotes intracellular invasion by group A streptococci.Infection and immunity · 2003Article
- Streptococcus pyogenes infection in mouse skin leads to a time-dependent up-regulation of protein H expression.Infection and immunity · 2003Article
- Cleavage of antigen-bound immunoglobulin G by SpeB contributes to streptococcal persistence in opsonizing blood.Infection and immunity · 2003Article
- Acquisition of regulators of complement activation by Streptococcus pyogenes serotype M1.Infection and immunity · 2002Article
- EndoS, a novel secreted protein from Streptococcus pyogenes with endoglycosidase activity on human IgG.The EMBO journal · 2001Article
- Identification and characterization of the scl gene encoding a group A Streptococcus extracellular protein virulence factor with similarity to human collagen.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface-associated M protein is a major virulence factor in Streptococcus pyogenes which confers bacterial resistance to phagocytosis. However, many S. pyogenes strains also express additional structurally related so-called M-like proteins. The strain studied here is of the clinically important M1 serotype and expresses two structurally related surface proteins, the M1 protein and protein H. Mutants were generated that expressed only one or none of these proteins at the bacterial surface. For survival in human blood either protein H or M1 protein was sufficient, whereas the double mutant was rapidly killed. The protein-binding properties of protein H, M1 protein, and the mutants suggest that bacterial binding of immunoglobulin G and factor H or factor H-like protein 1, which are regulatory proteins in the complement system, contribute to the antiphagocytic property.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.