ArticleInfection and immunity1999
Interleukin-10 and antigen-presenting cells actively suppress Th1 cells in BALB/c mice infected with the filarial parasite Brugia pahangi.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 76 citations in OpenAlex.
- Molecular Characterization of aGenes · 2019Article
- Infective Larvae ofFrontiers in immunology · 2018Article
- Biochemical and immunological characterization of annexin B30 from Clonorchis sinensis excretory/secretory products.Parasitology research · 2014Article
- Regulatory T cell subsets in filarial infection and their function.Frontiers in immunology · 2013Review
- Human and animal dirofilariasis: the emergence of a zoonotic mosaic.Clinical microbiology reviews · 2012Review
- Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.Journal of biomedicine & biotechnology · 2010Review
- Immunopathology of Dirofilaria immitis infection.Veterinary research communications · 2007Review
- Role of helminths in regulating mucosal inflammation.Springer seminars in immunopathology · 2005Review
- Regulatory T cells modulate Th2 responses induced by Brugia pahangi third-stage larvae.Infection and immunity · 2005Article
- Promoter haplotypes of the interleukin-10 gene influence proliferation of peripheral blood cells in response to helminth antigen.Genes and immunity · 2004Article
- Impairment of tetanus-specific cellular and humoral responses following tetanus vaccination in human lymphatic filariasis.Infection and immunity · 2004Article
- Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans.Infection and immunity · 2004Article
- Parasite-specific immunomodulatory functions of filarial cystatin.Infection and immunity · 2003Article
- Differential cytokine and antibody responses to adult and larval stages of Onchocerca volvulus consistent with the development of concomitant immunity.Infection and immunity · 2002Article
- Immunology of parasitic helminth infections.Infection and immunity · 2002Review
- Down-regulated lymphoproliferation coincides with parasite maturation and with the collapse of both gamma interferon and interleukin-4 responses in a bovine model of onchocerciasis.Infection and immunity · 2001Article
- Modulation of cytokine release in ex vivo-stimulated blood from borreliosis patients.Infection and immunity · 2001Article
- NO contributes to proliferative suppression in a murine model of filariasis.Infection and immunity · 2000Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Infection with the third-stage larvae (L3) of the filarial nematode Brugia results in a Th2-biased immune response in mice and humans. Previously we have shown that the production of interleukin 4 (IL-4) is critical for down-regulating polyclonal Th1 responses in L3-infected mice. However, the in vitro neutralization of IL-4 did not fully recover the defective polyclonal Th1 responses, nor did it result in the production of any antigen (Ag)-specific Th1 cytokines, suggesting that perhaps infection with L3 does not result in priming of Th1 cells in vivo. In this study, we analyzed the role of IL-10 and Ag-presenting cells (APCs) in the spleen as additional factors controlling the Th2 bias in infected mice. Our data show that IL-10 and APCs also contribute to the suppression of mitogen-driven Th1 responses of spleen cells from infected mice. In addition, the neutralization of IL-10 or the replacement of the resident APC population from spleen cell cultures resulted in the production of Ag-specific Th1 cytokines. Irradiated spleen cells from either L3-infected or uninfected mice were able to restore Ag-specific Th1 responses in vitro. Therefore, it appears that Brugia-reactive Th1 cells are primed following infection with L3, but are actively suppressed in vivo by a mechanism that involves IL-10 and the resident APC population, but not IL-4. These results indicate that a complex interplay of cytokines and cell populations underscores the Th2-polarized response in L3-infected mice.
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