ArticleInfection and immunity1999
Febrile-range temperature modifies early systemic tumor necrosis factor alpha expression in mice challenged with bacterial endotoxin.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 81 citations in OpenAlex.
- Fever-like temperatures improve cognitive deficits in the Scn2a autism mouse model via increases in potassium channel activity.Molecular psychiatry · 2026Article
- Topical application of Glauber's salt accelerates the absorption of abdominal fluid after pancreatectomy.BMC surgery · 2024Article
- Hyperthermia PreventsMicrobiology spectrum · 2023Article
- Perinatal Infection: A Major Contributor to Efficacy of Cooling in Newborns Following Birth Asphyxia.International journal of molecular sciences · 2021Review
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- [Is control fever mandatory in severe infections?]Reanimation : journal de la Societe de reanimation de langue francaise · 2016Article
- Shifts in temperature within the physiologic range modify strand-specific expression of select human microRNAs.RNA (New York, N.Y.) · 2015Article
- The two faces of IL-6 in the tumor microenvironment.Seminars in immunology · 2014Review
- Cytokine response to acute running in recreationally-active and endurance-trained men.European journal of applied physiology · 2013Article
- Low-level laser therapy improves crescentic glomerulonephritis in rats.Lasers in medical science · 2013Article
- Elevation in body temperature to fever range enhances and prolongs subsequent responsiveness of macrophages to endotoxin challenge.PloS one · 2012Article
- Opposing roles for heat and heat shock proteins in macrophage functions during inflammation: a function of cell activation state?Frontiers in immunology · 2012Article
- Death receptors mediate the adverse effects of febrile-range hyperthermia on the outcome of lipopolysaccharide-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Response of mice to continuous 5-day passive hyperthermia resembles human heat acclimation.Cell stress & chaperones · 2011Article
- Febrile range temperature represses TNF-alpha gene expression in LPS-stimulated macrophages by selectively blocking recruitment of Sp1 to the TNF-alpha promoter.Cell stress & chaperones · 2010Article
- Neonatal programming by neuroimmune challenge: effects on responses and tolerance to septic doses of lipopolysaccharide in adult male and female rats.Journal of neuroendocrinology · 2010Article
- Diverse immune mechanisms may contribute to the survival benefit seen in cancer patients receiving hyperthermia.Immunologic research · 2010Review
- Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters.American journal of physiology. Cell physiology · 2010Article
- Hyperthermia in the febrile range induces HSP72 expression proportional to exposure temperature but not to HSF-1 DNA-binding activity in human lung epithelial A549 cells.Cell stress & chaperones · 2009Article
- Bronchoconstriction induced by hyperventilation with humidified hot air: role of TRPV1-expressing airway afferents.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fever improves survival in acute infections, but the effects of increased core temperature on host defenses are poorly understood. Tumor necrosis factor alpha (TNF-alpha) is an early activator of host defenses and a major endogenous pyrogen. TNF-alpha expression is essential for survival in bacterial infections but, if disregulated, can cause tissue injury. In this study, we show that passively increasing core temperature in mice from the basal (36.5 to 37.5 degrees C) to the febrile (39.5 to 40 degrees C) range modifies systemic TNF-alpha expression in response to bacterial endotoxin (lipopolysaccharide). The early TNF-alpha secretion rate is enhanced, but the duration of maximal TNF-alpha production is shortened. We identified Kupffer cells as the predominant source of the excess TNF-alpha production in the warmer animals. The enhanced early TNF-alpha production observed at the higher temperature in vivo could not be demonstrated in isolated Kupffer cells or in precision-cut liver slices in vitro, indicating the participation of indirect pathways. Therefore, expression of the endogenous pyrogen TNF-alpha is regulated by increments in core temperature during fever, generating an enhanced early, self-limited TNF-alpha pulse.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.