ArticleMolecular and cellular biology1999
Transcriptional activation by ETS and leucine zipper-containing basic helix-loop-helix proteins.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- 5mC and H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma.Biomarker research · 2022Article
- ETV6 germline mutations cause HDAC3/NCOR2 mislocalization and upregulation of interferon response genes.JCI insight · 2020Article
- TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas.Journal of experimental & clinical cancer research : CR · 2019Article
- Transcription Factor ETS-1 and Reactive Oxygen Species: Role in Vascular and Renal Injury.Antioxidants (Basel, Switzerland) · 2018Review
- Molecular genetics and cellular features of TFE3 and TFEB fusion kidney cancers.Nature reviews. Urology · 2014Review
- Review of Ets1 structure, function, and roles in immunity.Cellular and molecular life sciences : CMLS · 2013Review
- Ets-1 is required for the activation of VEGFR3 during latent Kaposi's sarcoma-associated herpesvirus infection of endothelial cells.Journal of virology · 2013Article
- Regulation of endothelial cell development by ETS transcription factors.Seminars in cell & developmental biology · 2011Review
- Identification of interacting transcription factors regulating tissue gene expression in human.BMC genomics · 2010Article
- Mi2beta shows chromatin enzyme specificity by erasing a DNase I-hypersensitive site established by ACF.The Journal of biological chemistry · 2009Article
- Characterization of an Oct1 orthologue in the channel catfish, Ictalurus punctatus: a negative regulator of immunoglobulin gene transcription?BMC molecular biology · 2007Article
- Combinatorial gene control involving E2F and E Box family members.The EMBO journal · 2004Article
- The biology of the Ets1 proto-oncogene.Molecular cancer · 2003Review
- PSF-TFE3 oncoprotein in papillary renal cell carcinoma inactivates TFE3 and p53 through cytoplasmic sequestration.Oncogene · 2003Article
- PRCC, the commonest TFE3 fusion partner in papillary renal carcinoma is associated with pre-mRNA splicing factors.Oncogene · 2001Article
- Article
- Review
- Transcriptional control by the TGF-beta/Smad signaling system.The EMBO journal · 2000Review
- Phosphorylation represses Ets-1 DNA binding by reinforcing autoinhibition.Genes & development · 2000Article
- Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor alpha2.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The immunoglobulin mu heavy-chain gene enhancer contains closely juxtaposed binding sites for ETS and leucine zipper-containing basic helix-loop-helix (bHLH-zip) proteins. To understand the mu enhancer function, we have investigated transcription activation by the combination of ETS and bHLH-zip proteins. The bHLH-zip protein TFE3, but not USF, cooperated with the ETS domain proteins PU.1 and Ets-1 to activate a tripartite domain of this enhancer. Deletion mutants were used to identify the domains of the proteins involved. Both TFE3 and USF enhanced Ets-1 DNA binding in vitro by relieving the influence of an autoinhibitory domain in Ets-1 by direct protein-protein associations. Several regions of Ets-1 were found to be necessary, whereas the bHLH-zip domain was sufficient for this effect. Our studies define novel interactions between ETS and bHLH-zip proteins that may regulate combinatorial transcription activation by these protein families.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.