ArticleMolecular and cellular biology1999
Design of conditionally active STATs: insights into STAT activation and gene regulatory function.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 53 citations in OpenAlex.
- Differentiation of Subclinical Ketosis and Liver Function Test Indices in Adipose Tissues Associated With Hyperketonemia in Postpartum Dairy Cattle.Frontiers in veterinary science · 2021Article
- Crosstalk between STAT5 activation and PI3K/AKT functions in normal and transformed mammary epithelial cells.Molecular and cellular endocrinology · 2017Review
- Effects of insulin and IGF-I on growth hormone- induced STAT5 activation in 3T3-F442A adipocytes.Lipids in health and disease · 2013Article
- Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling.BMC bioinformatics · 2013Article
- Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Principles of interleukin (IL)-6-type cytokine signalling and its regulation.The Biochemical journal · 2003Review
- DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1.Genes & development · 2003Article
- Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha.The EMBO journal · 2002Article
- A completely foreign receptor can mediate an interferon-gamma-like response.The EMBO journal · 2001Article
- Nucleocytoplasmic shuttling of endocytic proteins.The Journal of cell biology · 2001Article
- Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.The Journal of clinical investigation · 2001Article
- Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain.Molecular and cellular biology · 2000Article
- Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor.The EMBO journal · 2000Article
- Serine phosphorylation of STATs.Oncogene · 2000Review
- Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Cell nucleus in context.Critical reviews in eukaryotic gene expression · 2000Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The STAT (signal transducer and activator of transcription) signaling pathway is activated by a large number of cytokines and growth factors. We sought to design a conditionally active STAT that could not only provide insight into basic questions about STAT function but also serve as a powerful tool to determine the precise biological role of STATs. To this end, we have developed a conditionally active STAT by fusing STATs with the ligand-binding domain of the estrogen receptor (ER). We have demonstrated that the resulting STAT-ER chimeras are estrogen-inducible transcription factors that retain the functional and biochemical characteristics of the cognate wild-type STATs. In addition, these tools have allowed us to evaluate separately the contribution of tyrosine phosphorylation and dimerization to STAT function. We have for the first time provided experimental data supporting the model that the only apparent role of STAT tyrosine phosphorylation is to drive dimerization, as dimerization alone is sufficient to unmask a latent STAT nuclear localization sequence and induce nuclear translocation, sequence-specific DNA binding, and transcriptional activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.