ArticleMolecular and cellular biology1999
Multiple layers of cooperativity regulate enhanceosome-responsive RNA polymerase II transcription complex assembly.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Orthogonal control of gene expression in plants using synthetic promoters and CRISPR-based transcription factors.Plant methods · 2022Article
- Genome reading by the NF-κB transcription factors.Nucleic acids research · 2019Review
- Article
- Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas.ACS synthetic biology · 2013Article
- Controlling a master switch of adipocyte development and insulin sensitivity: covalent modifications of PPARγ.Biochimica et biophysica acta · 2012Review
- Proinflammatory cytokines enhance estrogen-dependent expression of the multidrug transporter gene ABCG2 through estrogen receptor and NF{kappa}B cooperativity at adjacent response elements.The Journal of biological chemistry · 2010Article
- Progesterone receptor action in leiomyoma and endometrial cancer.Progress in molecular biology and translational science · 2009Review
- Transient HMGB protein interactions with B-DNA duplexes and complexes.Biochemical and biophysical research communications · 2008Article
- A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1.Nucleic acids research · 2005Article
- The DNA architectural protein HMGB1 facilitates RTA-mediated viral gene expression in gamma-2 herpesviruses.Journal of virology · 2004Article
- Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly.Molecular and cellular biology · 2004Article
- Interleukin-10 inhibits interleukin-12 p40 gene transcription by targeting a late event in the activation pathway.Molecular and cellular biology · 2004Article
- Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- TFIID and human mediator coactivator complexes assemble cooperatively on promoter DNA.Genes & development · 2002Article
- The DNA architectural protein HMGB1 displays two distinct modes of action that promote enhanceosome assembly.Molecular and cellular biology · 2002Article
- NF-kappa B activates prostate-specific antigen expression and is upregulated in androgen-independent prostate cancer.Molecular and cellular biology · 2002Article
- Mechanism for specificity by HMG-1 in enhanceosome assembly.Molecular and cellular biology · 2000Article
- The role of AHA motifs in the activator function of tomato heat stress transcription factors HsfA1 and HsfA2.The Plant cell · 2000Article
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Authors and funding
4 authors.
Funding
Abstract
Two coordinate forms of transcriptional synergy mediate eukaryotic gene regulation: the greater-than-additive transcriptional response to multiple promoter-bound activators, and the sigmoidal response to increasing activator concentration. The mechanism underlying the sigmoidal response has not been elucidated but is almost certainly founded on the cooperative binding of activators and the general machinery to DNA. Here we explore that mechanism by using highly purified transcription factor preparations and a strong Epstein-Barr virus promoter, BHLF-1, regulated by the virally encoded activator ZEBRA. We demonstrate that two layers of cooperative binding govern transcription complex assembly. First, the architectural proteins HMG-1 and -2 mediate cooperative formation of an enhanceosome containing ZEBRA and cellular Sp1. This enhanceosome then recruits transcription factor IIA (TFIIA) and TFIID to the promoter to form the DA complex. The DA complex, however, stimulates assembly of the enhanceosome itself such that the entire reaction can occur in a highly concerted manner. The data reveal the importance of reciprocal cooperative interactions among activators and the general machinery in eukaryotic gene regulation.
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