ArticleMolecular and cellular biology1999
Parental allele-specific chromatin configuration in a boundary-imprinting-control element upstream of the mouse H19 gene.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Review
- Conditional depletion of macrophages ameliorates cholestatic liver injury and fibrosis via lncRNA-H19.Cell death & disease · 2021Article
- Long non-coding RNA H19 deficiency ameliorates bleomycin-induced pulmonary inflammation and fibrosis.Respiratory research · 2020Article
- CTCF modulates allele-specific sub-TAD organization and imprinted gene activity at the mouse Dlk1-Dio3 and Igf2-H19 domains.Genome biology · 2019Article
- Long Noncoding RNA H19 Contributes to Cholangiocyte Proliferation and Cholestatic Liver Fibrosis in Biliary Atresia.Hepatology (Baltimore, Md.) · 2019Article
- Mouse Parthenogenetic Embryonic Stem Cells with Biparental-Like Expression of Imprinted Genes Generate Cortical-Like Neurons That Integrate into the Injured Adult Cerebral Cortex.Stem cells (Dayton, Ohio) · 2018Article
- Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Global epigenomic analysis indicates that epialleles contribute to Allele-specific expression via Allele-specific histone modifications in hybrid rice.BMC genomics · 2015Article
- Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases.BioMed research international · 2015Review
- A complex deoxyribonucleic acid looping configuration associated with the silencing of the maternal Igf2 allele.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.Genome research · 2005Article
- Functional characterization of a novel Ku70/80 pause site at the H19/Igf2 imprinting control region.Molecular and cellular biology · 2005Article
- Evolution of the Beckwith-Wiedemann syndrome region in vertebrates.Genome research · 2005Article
- The H19 differentially methylated region marks the parental origin of a heterologous locus without gametic DNA methylation.Molecular and cellular biology · 2004Article
- Tissue-specific and imprinted epigenetic modifications of the human NDN gene.Nucleic acids research · 2004Article
- Epigenetic properties and identification of an imprint mark in the Nesp-Gnasxl domain of the mouse Gnas imprinted locus.Molecular and cellular biology · 2003Article
- Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.Genes & development · 2003Article
- Multiple nucleosome positioning sites regulate the CTCF-mediated insulator function of the H19 imprinting control region.Molecular and cellular biology · 2002Article
- Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting.Molecular and cellular biology · 2002Article
- Methylation-dependent silencing at the H19 imprinting control region by MeCP2.Nucleic acids research · 2002Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mouse H19 gene is expressed from the maternal chromosome exclusively. A 2-kb region at 2 to 4 kb upstream of H19 is paternally methylated throughout development, and these sequences are necessary for the imprinted expression of both H19 and the 5'-neighboring Igf2 gene. In particular, on the maternal chromosome this element appears to insulate the Igf2 gene from enhancers located downstream of H19. We analyzed the chromatin organization of this element by assaying its sensitivity to nucleases in nuclei. Six DNase I hypersensitive sites (HS sites) were detected on the unmethylated maternal chromosome exclusively, the two most prominent of which mapped 2.25 and 2.75 kb 5' to the H19 transcription initiation site. Five of the maternal HS sites were present in expressing and nonexpressing tissues and in embryonic stem (ES) cells. They seem, therefore, to reflect the maternal origin of the chromosome rather than the expression of H19. A sixth maternal HS site, at 3.45 kb upstream of H19, was detected in ES cells only. The nucleosomal organization of this element was analyzed in tissues and ES cells by micrococcal nuclease digestion. Specifically on the maternal chromosome, an unusual and strong banding pattern was obtained, suggestive of a nonnucleosomal organization. From our studies, it appears that the unusual chromatin organization with the presence of HS sites (maternal chromosome) and DNA methylation (paternal chromosome) in this element are mutually exclusive and reflect alternate epigenetic states. In addition, our data suggest that nonhistone proteins are associated with the maternal chromosome and that these might be involved in its boundary function.
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