ArticleMolecular and cellular biology1999
The schizosaccharomyces pombe dim1(+) gene interacts with the anaphase-promoting complex or cyclosome (APC/C) component lid1(+) and is required for APC/C function.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Identification and characterization ofmicroPublication biology · 2026Article
- The expression pattern of OsDim1 in rice and its proposed function.Scientific reports · 2019Article
- In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.Molecular psychiatry · 2015Article
- Defective entry into mitosis 1 (Dim1) negatively regulates osteoclastogenesis by inhibiting the expression of nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 (NFATc1).The Journal of biological chemistry · 2014Article
- Histone H2B ubiquitination promotes the function of the anaphase-promoting complex/cyclosome in Schizosaccharomyces pombe.G3 (Bethesda, Md.) · 2014Article
- An E2 enzyme Ubc11 is required for ubiquitination of Slp1/Cdc20 and spindle checkpoint silencing in fission yeast.Cell cycle (Georgetown, Tex.) · 2013Article
- Cooperation between the septins and the actomyosin ring and role of a cell-integrity pathway during cell division in fission yeast.Genetics · 2010Article
- A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.Molecular and cellular biology · 2009Article
- Nuc2p, a subunit of the anaphase-promoting complex, inhibits septation initiation network following cytokinesis in fission yeast.PLoS genetics · 2008Article
- Structural organization of the anaphase-promoting complex bound to the mitotic activator Slp1.Molecular cell · 2007Article
- Fission yeast Dss1 associates with the proteasome and is required for efficient ubiquitin-dependent proteolysis.The Biochemical journal · 2006Article
- Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex.Eukaryotic cell · 2005Article
- Fission yeast Clp1p phosphatase affects G2/M transition and mitotic exit through Cdc25p inactivation.The EMBO journal · 2004Article
- Two classes of the CDh1-type activators of the anaphase-promoting complex in plants: novel functional domains and distinct regulation.The Plant cell · 2004Article
- An anillin homologue, Mid2p, acts during fission yeast cytokinesis to organize the septin ring and promote cell separation.The Journal of cell biology · 2003Article
- Disruption and overexpression of the Schizosaccharomyces pombe aps1 gene, and effects on growth rate, morphology and intracellular diadenosine 5',5"'-P1,P5-pentaphosphate and diphosphoinositol polyphosphate concentrations.The Biochemical journal · 2003Article
- Characterization of interactions among the Cef1p-Prp19p-associated splicing complex.RNA (New York, N.Y.) · 2002Article
- Study of cyclin proteolysis in anaphase-promoting complex (APC) mutant cells reveals the requirement for APC function in the final steps of the fission yeast septation initiation network.Molecular and cellular biology · 2001Article
- APC(ste9/srw1) promotes degradation of mitotic cyclins in G(1) and is inhibited by cdc2 phosphorylation.The EMBO journal · 2000Article
- The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast.The EMBO journal · 2000Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Schizosaccharomyces pombe dim1(+) gene is required for entry into mitosis and for chromosome segregation during mitosis. To further understand dim1p function, we undertook a synthetic lethal screen with the temperature-sensitive dim1-35 mutant and isolated lid (for lethal in dim1-35) mutants. Here, we describe the temperature-sensitive lid1-6 mutant. At the restrictive temperature of 36 degrees C, lid1-6 mutant cells arrest with a "cut" phenotype similar to that of cut4 and cut9 mutants. An epitope-tagged version of lid1p is a component of a multiprotein approximately 20S complex; the presence of lid1p in this complex depends upon functional cut9(+). lid1p-myc coimmunoprecipitates with several other proteins, including cut9p and nuc2p, and the presence of cut9p in a 20S complex depends upon the activity of lid1(+). Further, lid1(+) function is required for the multiubiquitination of cut2p, an anaphase-promoting complex or cyclosome (APC/C) target. Thus, lid1p is a component of the S. pombe APC/C. In dim1 mutants, the abundances of lid1p and the APC/C complex decline significantly, and the ubiquitination of an APC/C target is abolished. These data suggest that at least one role of dim1p is to maintain or establish the steady-state level of the APC/C.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.