Evidence map›Paper›PMID 10080163›Full record

ArticleDigestive diseases and sciences1999

Characterization of two novel proabsorptive peptide YY analogs, BIM-43073D and BIM-43004C.

D A Litvak, H Iseki, B M Evers, G H Greeley, M R Hellmich, K Iwase, A Balasubramaniam, C M Townsend

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Neuropeptide Y Y2 receptor in health and disease.British journal of pharmacology · 2008
    Review
  3. Management of patients with a short bowel.World journal of gastroenterology · 2001
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

D A LitvakDepartment of Surgery, The University of Texas Medical Branch, Galveston 77555-0527, USA.
H Iseki
B M Evers
G H Greeley
M R Hellmich
K Iwase
A Balasubramaniam
C M Townsend
The University of Texas Medical Branch at Galveston · USUniversity of Cincinnati · USUniversity of Cincinnati Medical Center · US

Funding

TISSUE CULTURE COREP01DK035608 · NIDDK · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HELLMICH, MARK R · 1986 to 2010
$14.0M
STRUCTURE/ACTIVITY STUDIES OF NPYR01GM047122 · NIGMS · UNIVERSITY OF CINCINNATI · PI BALASUBRAMANIAM, AMBIKAIPAKAN · 1993 to 2001
$325k
NIDDK NIH HHS P01 DK35608NIDDK NIH HHS T32-DK07633NIGMS NIH HHS GM47122
6 · The paper itself

Abstract

Effective clinical therapy to augment intestinal absorption of water and electrolytes does not exist; the gut hormone, peptide YY (PYY), is a potent proabsorptive agent in animal models. The purpose of our study was to evaluate the effects of two novel PYY analogs, BIM-43073D and BIM-43004C, on intestinal absorption. Dogs with ileal Thiry-Vella fistulae (TVF) were treated with either PYY, BIM-43073D, or BIM-43004C. Administration of BIM-43073D significantly increased water and sodium absorption over baseline and maintained this level of increased absorption for a longer duration than an equimolar dose of PYY. Administration of BIM-43004C significantly increased sodium and water absorption over baseline at a level equal to that of PYY. The novel PYY analogs, BIM-43073D and BIM-43004C, are effective proabsorptive agents with BIM-43073D producing more sustained effects than PYY. These compounds may be clinically useful in the treatment of gut malabsorption in conditions such as cholera, Crohn's disease, and the short-bowel syndrome.

Indexed as

AnimalsDogsFemaleIleal DiseasesIntercellular Signaling Peptides and ProteinsIntestinal AbsorptionIntestinal FistulaMalabsorption SyndromesPeptidesPeptide YYWater-Electrolyte BalanceBIM 43004-1BIM 43073DIntercellular Signaling Peptides and ProteinsPeptidesPeptide YY

Identifiers

PMID10080163
OpenAlexW177724895

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.