ArticleDigestive diseases and sciences1999
Apoptosis in Helicobacter pylori-associated gastric and duodenal ulcer disease is mediated via the Fas antigen pathway.
Article in Digestive diseases and sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 71 citations in OpenAlex.
- Viruses, Other Pathogenic Microorganisms and Esophageal Cancer.Gastrointestinal tumors · 2015Review
- Helicobacter pylori vacuolating toxin A and apoptosis.Cell communication and signaling : CCS · 2011Article
- Helicobacter pylori and gastric cancer: factors that modulate disease risk.Clinical microbiology reviews · 2010Review
- T-bet knockout prevents Helicobacter felis-induced gastric cancer.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- H. pylori-induced apoptosis in human gastric cancer cells mediated via the release of apoptosis-inducing factor from mitochondria.Helicobacter · 2008Article
- Interaction of Helicobacter pylori with gastric epithelial cells is mediated by the p53 protein family.Gastroenterology · 2008Article
- Distinct patterns of mucosal apoptosis in H pylori-associated gastric ulcer are associated with altered FasL and perforin cytotoxic pathways.World journal of gastroenterology · 2006Article
- Helicobacter pylori induces apoptosis of T- and B-cell lines and translocates mitochondrial apoptosis-inducing factor to nucleus.Current microbiology · 2006Article
- Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation.Infection and immunity · 2005Article
- Article
- Helicobacter pylori induces apoptosis of macrophages in association with alterations in the mitochondrial pathway.Infection and immunity · 2004Article
- Effect of Helicobacter pylori infection on expression of Bcl-2 family members in gastric adenocarcinoma.World journal of gastroenterology · 2004Article
- Helicobacter pylori disrupts STAT1-mediated gamma interferon-induced signal transduction in epithelial cells.Infection and immunity · 2004Article
- Apoptosis of gastric lymphocytes in Helicobacter pylori-infected rhesus macaques.Digestive diseases and sciences · 2003Article
- Increased apoptosis in gastric mucosa adjacent to intestinal metaplasia.Journal of clinical pathology · 2003Article
- Enhanced disease severity in Helicobacter pylori-infected mice deficient in Fas signaling.Infection and immunity · 2002Article
- Helicobacter pylori and acetylsalicylic acid synergistically accelerate apoptosis via Fas antigen pathway in rabbit gastric epithelial cells.Digestive diseases and sciences · 2002Article
- Helicobacter pylori and gastrointestinal tract adenocarcinomas.Nature reviews. Cancer · 2002Review
- Epithelial intestinal cell apoptosis induced by Helicobacter pylori depends on expression of the cag pathogenicity island phenotype.Infection and immunity · 2001Article
- Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions.Infection and immunity · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Increased mucosal apoptosis is seen in H. pylori-infected gastric tissue; however, the precise mechanism by which this organism triggers programmed cell death is poorly understood and is investigated in this study. One pathway for induction of apoptosis is the Fas Ag pathway. Normal gastric and small bowel tissue express low levels of Fas antigen and nondetectable levels of Fas ligand. Consequent to H. pylori infection, there is elevated expression of Fas antigen in mucosal cells concurrent with Fas ligand expressing lymphocytes. This prompted us to investigate the potential role of Fas in mediating H. pylori-related apoptosis. It has been shown that inflammatory cytokines are abundant in H. pylori-infected tissue and that cytokines regulate the expression of Fas Ag in various tissue types. Using cell culture, we examine the role of specific inflammatory cytokines in activating this pathway. This communication presents the first evidence to implicate the Fas pathway in mediating apoptosis in H. pylori-associated gastric and duodenal ulcer disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.