ArticleThe American journal of pathology1999
Exposure to hyperoxia decreases the expression of vascular endothelial growth factor and its receptors in adult rat lungs.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- Hyperoxia and pulmonary vascular injury in bronchopulmonary dysplasia: pathogenic mechanisms and emerging therapies-a systematic review.Pediatric research · 2026Pooled it
- Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.Pulmonary pharmacology & therapeutics · 2023Article
- Umbilical cord blood exosomes from very preterm infants with bronchopulmonary dysplasia aggravate lung injury in mice.Scientific reports · 2023Article
- NOX4 Mediates Epithelial Cell Death in Hyperoxic Acute Lung Injury Through Mitochondrial Reactive Oxygen Species.Frontiers in pharmacology · 2022Article
- Effect of low VEGF on lung development and function.Transgenic research · 2021Article
- Comparison of Mean VEGF-A Expression Between Acute Ischemic Stroke Patients and Non-Ischemic Stroke Subjects.Open access Macedonian journal of medical sciences · 2019Article
- Assessment of the Alveolar Capillary Network in the Postnatal Mouse Lung in 3D Using Serial Block-Face Scanning Electron Microscopy.Frontiers in physiology · 2019Article
- Mechanical ventilation strategies alter cardiovascular biomarkers in an infant rat model.Physiological reports · 2018Article
- Effects of trauma, hemorrhagic shock, and chronic stress on lung vascular endothelial growth factor.The Journal of surgical research · 2017Article
- Sequestration of Vascular Endothelial Growth Factor (VEGF) Induces Late Restrictive Lung Disease.PloS one · 2016Article
- The role of vascular endothelial growth factor receptor-1 signaling in compensatory contralateral lung growth following unilateral pneumonectomy.Laboratory investigation; a journal of technical methods and pathology · 2015Article
- Role of microRNA-150 and glycoprotein nonmetastatic melanoma protein B in angiogenesis during hyperoxia-induced neonatal lung injury.American journal of respiratory cell and molecular biology · 2015Article
- Postnatal hyperoxia exposure differentially affects hepatocytes and liver haemopoietic cells in newborn rats.PloS one · 2014Article
- Hypoxia-induced expression of VEGF splice variants and protein in four retinal cell types.Experimental eye research · 2013Article
- Neonatal hyperoxia causes pulmonary vascular disease and shortens life span in aging mice.The American journal of pathology · 2011Article
- The chitinase-like proteins breast regression protein-39 and YKL-40 regulate hyperoxia-induced acute lung injury.American journal of respiratory and critical care medicine · 2010Article
- Neonatal oxygen adversely affects lung function in adult mice without altering surfactant composition or activity.American journal of physiology. Lung cellular and molecular physiology · 2009Article
- Vascular endothelial growth factor receptor and coreceptor expression in human acute respiratory distress syndrome.Journal of critical care · 2009Article
- A protocol for a lung neovascularization model in rodents.Nature protocols · 2008Article
- Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling.American journal of respiratory and critical care medicine · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exposure to high levels of inspired oxygen leads to respiratory failure and death in many animal models. Endothelial cell death is an early finding, before the onset of respiratory failure. Vascular endothelial growth factor (VEGF) is highly expressed in the lungs of adult animals. In the present study, adult Sprague-Dawley rats were exposed to >95% FiO2 for 24 or 48 hours. Northern blot analysis revealed a marked reduction in VEGF mRNA abundance by 24 hours, which decreased to less than 50% of control by 48 hours. In situ hybridization revealed that VEGF was highly expressed in distal airway epithelial cells in controls but disappeared in the oxygen-exposed animals. Immunohistochemistry and Western blot analyses demonstrated that VEGF protein was decreased at 48 hours. TUNEL staining demonstrated the presence of apoptotic cells coincident with the decline in VEGF. Abundance of VEGF receptor mRNAs (Flt-1 and KDR/Flk) decreased in the late time points of the study (48 hours), possibly secondary to the loss of endothelial cells. We speculate that VEGF functions as a survival factor in the normal adult rat lung, and its loss during hyperoxia contributes to the pathophysiology of oxygen-induced lung damage.
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Registered trials
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