ArticleThe American journal of pathology1999
Podocalyxin in rat platelets and megakaryocytes.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 66 citations in OpenAlex.
- Visualization of choroidal vasculature in pigmented mouse eyes from experimental models of AMD.Experimental eye research · 2024Article
- CD34-Structure, Functions and Relationship with Cancer Stem Cells.Medicina (Kaunas, Lithuania) · 2023Review
- Podocalyxin Expressed in Antigen Presenting Cells Promotes Interaction With T Cells and Alters Centrosome Translocation to the Contact Site.Frontiers in immunology · 2022Article
- Podocalyxin in Normal Tissue and Epithelial Cancer.Cancers · 2021Review
- Emerging Role of Podocalyxin in the Progression of Mature B-Cell Non-Hodgkin Lymphoma.Cancers · 2020Review
- Review
- Serum podocalyxin levels correlate with carotid intima media thickness, implicating its role as a novel biomarker for atherosclerosis.Scientific reports · 2018Article
- Involvement of platelet-tumor cell interaction in immune evasion. Potential role of podocalyxin-like protein 1.Frontiers in oncology · 2014Review
- Urinary podocalyxin as a marker of preeclampsia in a Hispanic population.International journal of physiology, pathophysiology and pharmacology · 2014Article
- Podocalyxin-like protein expression in primary colorectal cancer and synchronous lymph node metastases.Diagnostic pathology · 2013Article
- Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.American journal of physiology. Cell physiology · 2012Article
- The anti-adhesive mucin podocalyxin may help initiate the transperitoneal metastasis of high grade serous ovarian carcinoma.Clinical & experimental metastasis · 2012Article
- Diminished thrombogenic responses by deletion of the Podocalyxin Gene in mouse megakaryocytes.PloS one · 2011Article
- Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.PloS one · 2010Article
- Identification and expression profiling of blood-brain barrier membrane proteins.Journal of neurochemistry · 2010Article
- Ubiquitous yet distinct expression of podocalyxin on vascular surfaces in normal and tumor tissues in the rat.Journal of vascular research · 2009Article
- Pleomorphic extra-renal manifestation of the glomerular podocyte marker podocalyxin in tissues of normal beagle dogs.Histochemistry and cell biology · 2007Article
- Article
- Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis.Immunologic research · 2006Review
- Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm.The American journal of pathology · 2001Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Podocalyxin is a membrane protein of rat podocytes and endothelial cells. It has not been described in other cell types, and no amino acid or DNA sequence data are available about it. Here we show that podocalyxin antigens are present in rat platelets and megakaryocytes. In resting platelets, the antigens are mainly intracellular but become surface exposed after thrombin stimulation, as shown by immunofluorescence and flow cytometry. By Western blotting, platelet podocalyxin has an apparent Mr of 140,000. Cytocentrifuge slides of rat bone marrow show that anti-podocalyxin antibodies recognize large polyploid cells also expressing CD62P, indicating that the cells are megakaryocytes. From a rat glomerular cDNA library we isolated a clone covering the carboxyl-terminal nucleotides of rat podocalyxin. Its putative transmembrane or intracellular domains are 100% or >93% identical, respectively, with the human and rabbit podocalyxin-like proteins. The truncated extracellular domain extends to include two of the four conserved cysteines shared by podocalyxin-like proteins. By Northern blotting, a 5.5-kb renal cortical transcript is seen. By in situ hybridization, cRNA probes recognize podocytes, endothelial cells, and megakaryocytes, and by reverse transcription polymerase chain reaction, platelets are shown to contain podocalyxin mRNA. Our results show that rat podocalyxin is a homologue of the previously cloned podocalyxin-like proteins and suggest that also in mammals podocalyxin has a role in hematopoiesis, as previously shown in the chicken.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.