ArticleThe American journal of pathology1999
Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 132 citations in OpenAlex.
- Direct Lineage Reprogramming: Harnessing Cell Plasticity between Liver and Pancreas.Cold Spring Harbor perspectives in biology · 2020Review
- Direct cell reprogramming for tissue engineering and regenerative medicine.Journal of biological engineering · 2019Review
- Transdifferentiation of pancreatic progenitor cells to hepatocyte-like cells is not serum-dependent when facilitated by extracellular matrix proteins.Scientific reports · 2018Article
- 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice.International journal of obesity (2005) · 2016Article
- Nonproliferative and Proliferative Lesions of the Gastrointestinal Tract, Pancreas and Salivary Glands of the Rat and Mouse.Journal of toxicologic pathology · 2016Review
- The GCTM-5 epitope associated with the mucin-like glycoprotein FCGBP marks progenitor cells in tissues of endodermal origin.Stem cells (Dayton, Ohio) · 2012Article
- Ontogenesis of hepatic and pancreatic stem cells.Stem cell reviews and reports · 2012Review
- A rare case of metastatic pancreatic hepatoid carcinoma treated with sorafenib.Journal of gastrointestinal cancer · 2012Article
- Disrupted pancreatic exocrine differentiation and malabsorption in response to chronic elevated systemic glucocorticoid.The American journal of pathology · 2010Article
- Stem cells and liver regeneration.Gastroenterology · 2009Review
- Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.PloS one · 2009Article
- Reversal of diabetes in mice by intrahepatic injection of bone-derived GFP-murine mesenchymal stem cells infected with the recombinant retrovirus-carrying human insulin gene.World journal of surgery · 2007Article
- Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer.The American journal of pathology · 2007Article
- Stem cells in the adult pancreas and liver.The Biochemical journal · 2007Review
- Role of FGF1, FGF2 and FGF7 in the development of the pancreas from control and streptozotocin-treated hamsters.Cell proliferation · 2006Article
- Cystic cholangiomas after transplantation of pancreatic islets into the livers of diabetic rats.Virchows Archiv : an international journal of pathology · 2006Article
- Pancreatic stem cells: differentiation options.Stem cell reviews · 2005Review
- Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Transdifferentiation, metaplasia and tissue regeneration.Organogenesis · 2004Article
- Adult bone marrow stromal cells in the embryonic brain: engraftment, migration, differentiation, and long-term survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Keratinocyte growth factor, (KGF), a member of the fibroblast growth factor (FGF) family, is involved in wound healing. It also promotes the differentiation of many epithelial tissues and proliferation of epithelial cells as well as pancreatic duct cells. Additionally, many members of the highly homologous FGF family (including KGF), influence both growth and cellular morphology in the developing embryo. We have previously observed elevated levels of KGF in our interferon-gamma transgenic mouse model of pancreatic regeneration. To understand the role of KGF in pancreatic differentiation, we generated insulin promoter-regulated KGF transgenic mice. Remarkably, we have found that ectopic KGF expression resulted in the emergence of hepatocytes within the islets of Langerhans in the pancreas. Additionally, significant intra-islet duct cell proliferation in the pancreata of transgenic KGF mice was observed. The unexpected appearance of hepatocytes and proliferation of intra-islet duct cells in the pancreata of these mice evidently stemmed directly from local exposure to KGF.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.