ArticleProceedings of the National Academy of Sciences of the United States of America1999
X chromosome evidence for ancient human histories.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
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- Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders.Scientific reports · 2017Article
- Signatures of human European Palaeolithic expansion shown by resequencing of non-recombining X-chromosome segments.European journal of human genetics : EJHG · 2017Article
- Within a sample from a population, the distribution of the number of descendants of a subsample's most recent common ancestor.Theoretical population biology · 2014Article
- Local selection of human populations shapes complex evolution patterns of CXCL10 gene.Immunogenetics · 2013Article
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- The date of interbreeding between Neandertals and modern humans.PLoS genetics · 2012Article
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- Analysis of 21 X-chromosomal STRs in an Algerian population sample.International journal of legal medicine · 2010Article
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- Origin and evolution of sulfadoxine resistant Plasmodium falciparum.PLoS pathogens · 2010Article
- Highly punctuated patterns of population structure on the X chromosome and implications for African evolutionary history.American journal of human genetics · 2010Article
- A population genetics study of the familial Mediterranean fever gene: evidence of balancing selection under an overdominance regime.Genes and immunity · 2009Article
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- Culture, population structure, and low genetic diversity in Pleistocene hominins.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Genetic structure in African populations: implications for human demographic history.Cold Spring Harbor symposia on quantitative biology · 2009Review
- Intergenic DNA sequences from the human X chromosome reveal high rates of global gene flow.BMC genetics · 2008Article
- Population genetic analysis of the N-acylsphingosine amidohydrolase gene associated with mental activity in humans.Genetics · 2008Article
7 more citing papers are in PubMed but not listed here.
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Abstract
Diverse African and non-African samples of the X-linked PDHA1 (pyruvate dehydrogenase E1 alpha subunit) locus revealed a fixed DNA sequence difference between the two sample groups. The age of onset of population subdivision appears to be about 200 thousand years ago. This predates the earliest modern human fossils, suggesting the transformation to modern humans occurred in a subdivided population. The base of the PDHA1 gene tree is relatively ancient, with an estimated age of 1.86 million years, a late Pliocene time associated with early species of Homo. PDHA1 revealed very low variation among non-Africans, but in other respects the data are consistent with reports from other X-linked and autosomal haplotype data sets. Like these other genes, but in conflict with microsatellite and mitochondrial data, PDHA1 does not show evidence of human population expansion.
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