ArticleProceedings of the National Academy of Sciences of the United States of America1999
EDS1, an essential component of R gene-mediated disease resistance in Arabidopsis has homology to eukaryotic lipases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 254 papers, 1 of them a synthesis that pooled it.
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254 citing papers in PubMed, 1 synthesis or guideline pooled it, 629 citations in OpenAlex.
- The Brassicaceae Family Displays Divergent, Shoot-Skewed NLR Resistance Gene Expression.Plant physiology · 2018Pooled it
- Mechanisms and balanced regulation of plant immunity.Nature reviews. Molecular cell biology · 2026Review
- A VvWRKY8-salicylic acid pathway amplification loop confers resistance to Plasmopara viticola in grapevine.Molecular horticulture · 2026Article
- The role of MLO in powdery mildew susceptibility depends on a combination of functional specialization and subcellular localization.Plant physiology · 2026Article
- β-Aminobutyric acid enhancesPlant biotechnology (Tokyo, Japan) · 2026Article
- Transition metal-enhanced immunity in Arabidopsis roots via an NLR pair.Nature plants · 2026Article
- Signaling Pathway Analysis and Downstream Genes Associated with Disease Resistance Mediated byPlants (Basel, Switzerland) · 2026Article
- Melatonin promotes stomatal immunity by mediating phytohormone crosstalk inFrontiers in plant science · 2026Article
- Take control of expression: effector-mediated modulation of the host transcriptional machinery.Frontiers in plant science · 2026Review
- Cold priming on pathogen susceptibility in the ArabidopsisPlant signaling & behavior · 2024Article
- Pathogen perception and signaling in plant immunity.The Plant cell · 2024Review
- Interplay of EXO70 and MLO proteins modulates trichome cell wall composition and susceptibility to powdery mildew.The Plant cell · 2024Article
- METACASPASE8 (MC8) Is a Crucial Protein in the LSD1-Dependent Cell Death Pathway in Response to Ultraviolet Stress.International journal of molecular sciences · 2024Article
- Foliar application of plant-derived peptides decreases the severity of leaf rust (Puccinia triticina) infection in bread wheat (Triticum aestivum L.).Journal, genetic engineering & biotechnology · 2024Article
- WRR4B contributes to a broad-spectrum disease resistance against powdery mildew in Arabidopsis.Molecular plant pathology · 2024Article
- Advancements in Research on Prevention and Control Strategies for Maize White Spot Disease.Genes · 2023Review
- Examining the Transcriptomic and Biochemical Signatures ofInternational journal of molecular sciences · 2023Article
- Signaling and Resistosome Formation in Plant Innate Immunity to Viruses: Is There a Common Mechanism of Antiviral Resistance Conserved across Kingdoms?International journal of molecular sciences · 2023Review
- The flowering time regulator FLK controls pathogen defense in Arabidopsis thaliana.Plant physiology · 2023Article
- A splicing variant of EDS1 from Vitis vinifera forms homodimers but no heterodimers with PAD4.Protein science : a publication of the Protein Society · 2023Article
194 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A major class of plant disease resistance (R) genes encodes leucine-rich-repeat proteins that possess a nucleotide binding site and amino-terminal similarity to the cytoplasmic domains of the Drosophila Toll and human IL-1 receptors. In Arabidopsis thaliana, EDS1 is indispensable for the function of these R genes. The EDS1 gene was cloned by targeted transposon tagging and found to encode a protein that has similarity in its amino-terminal portion to the catalytic site of eukaryotic lipases. Thus, hydrolase activity, possibly on a lipid-based substrate, is anticipated to be central to EDS1 function. The predicted EDS1 carboxyl terminus has no significant sequence homologies, although analysis of eight defective eds1 alleles reveals it to be essential for EDS1 function. Two plant defense pathways have been defined previously that depend on salicylic acid, a phenolic compound, or jasmonic acid, a lipid-derived molecule. We examined the expression of EDS1 mRNA and marker mRNAs (PR1 and PDF1.2, respectively) for these two pathways in wild-type and eds1 mutant plants after different challenges. The results suggest that EDS1 functions upstream of salicylic acid-dependent PR1 mRNA accumulation and is not required for jasmonic acid-induced PDF1.2 mRNA expression.
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