ArticleProceedings of the National Academy of Sciences of the United States of America1999
Modulation of glycine receptors in retinal ganglion cells by zinc.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 51 citations in OpenAlex.
- Light responses and amacrine cell modulation of morphologically-identified retinal ganglion cells in the mouse retina.Vision research · 2023Article
- Neuromodulation: Actions of Dopamine, Retinoic Acid, Nitric Oxide, and Other Substances on Retinal Horizontal Cells.Eye and brain · 2023Review
- Mobile zinc as a modulator of sensory perception.FEBS letters · 2023Review
- Effects of Iron and Zinc on Mitochondria: Potential Mechanisms of Glaucomatous Injury.Frontiers in cell and developmental biology · 2021Review
- Modulation of Gpr39, a G-protein coupled receptor associated with alcohol use in non-human primates, curbs ethanol intake in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease.International journal of molecular sciences · 2018Review
- Zinc and zinc chelators modify taurine transport in rat retinal cells.Neurochemical research · 2014Article
- Review: Zinc's functional significance in the vertebrate retina.Molecular vision · 2014Review
- Zinc modulation of hemi-gap-junction channel currents in retinal horizontal cells.Journal of neurophysiology · 2009Article
- Zinc-mediated feedback at the synaptic terminals of vertebrate photoreceptors.Experimental eye research · 2008Article
- GABA(A), GABA(C) and glycine receptor-mediated inhibition differentially affects light-evoked signalling from mouse retinal rod bipolar cells.The Journal of physiology · 2006Article
- Molecular determinants of glycine receptor alphabeta subunit sensitivities to Zn2+-mediated inhibition.The Journal of physiology · 2005Article
- Endogenous zinc can be a modulator of glycinergic signaling pathway in the rat retina.Journal of molecular histology · 2005Article
- Selective antagonism of rat inhibitory glycine receptor subunits.The Journal of physiology · 2004Article
- Müller cell zinc transporter-3 labeling suggests a role in outer retina zinc homeostasis.Molecular medicine (Cambridge, Mass.)Article
- The zinc sensing receptor, a link between zinc and cell signaling.Molecular medicine (Cambridge, Mass.)Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Effects of zinc, an endogenous neuromodulator in the central nervous system, on glycine receptors (GlyRs) in retinal ganglion cells were investigated by using the whole-cell voltage-clamp technique. Zn2+ at low concentration (<2 microM) potentiated the glycine-induced chloride current and at higher concentration (>10 microM) suppressed it. This biphasic regulatory action of zinc acted selectively on the fast component of the glycine-induced current mediated by the strychnine-sensitive GlyRs, but not on the slow component mediated by the 5,7-dichlorokynurenic acid-sensitive GlyRs. Dose-response studies showed that 1 microM Zn2+ increased the maximum glycine response (I approximately) and shifted the EC50 to the left, suggesting that Zn2+ at low concentrations acts as an allosteric activator of the strychnine-sensitive GlyRs. Zn2+ at a concentration of 100 microM did not alter I approximately and shifted the EC50 to the right, indicating that Zn2+ at high concentrations acts as a competitive inhibitor of the GlyRs. Physiological functions of zinc modulation of GlyRs in retinal ganglion cells are discussed.
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