ArticleProceedings of the National Academy of Sciences of the United States of America1999
Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 218 citations in OpenAlex.
- Article
- KLK4T2 Is a Hormonally Regulated Transcript from theInternational journal of molecular sciences · 2021Article
- Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2.Journal of medical virology · 2021Review
- Crystal structure of the inhibitor-free form of the serine protease kallikrein-4.Acta crystallographica. Section F, Structural biology communications · 2019Article
- Ethnicity and ERG frequency in prostate cancer.Nature reviews. Urology · 2018Review
- Nanostructured Ti surfaces and retinoic acid/dexamethasone present a spatial framework for the maturation and amelogenesis of LS-8 cells.International journal of nanomedicine · 2018Article
- Fluoride Alters Klk4 Expression in Maturation Ameloblasts through Androgen and Progesterone Receptor Signaling.Frontiers in physiology · 2017Article
- Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.American journal of cancer research · 2017Article
- Globoside accelerates the differentiation of dental epithelial cells into ameloblasts.International journal of oral science · 2016Article
- Chemical Component and Proteomic Study of the Amphibalanus (= Balanus) amphitrite Shell.PloS one · 2015Article
- Structure-function analyses of human kallikrein-related peptidase 2 establish the 99-loop as master regulator of activity.The Journal of biological chemistry · 2014Article
- Dental enamel development: proteinases and their enamel matrix substrates.ISRN dentistry · 2013Review
- Aberrant PSA glycosylation--a sweet predictor of prostate cancer.Nature reviews. Urology · 2013Review
- Protein-mediated enamel mineralization.Frontiers in bioscience (Landmark edition) · 2012Review
- Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients.Cancer immunology, immunotherapy : CII · 2012Article
- Article
- Expression of kallikrein-related peptidase 4 in dental and non-dental tissues.European journal of oral sciences · 2011Article
- A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells.RNA (New York, N.Y.) · 2010Article
- Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis.Biological chemistry · 2010Review
- Optimization of peptide-based inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate cancer.Bioorganic & medicinal chemistry · 2009Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The identification of genes with selective expression in specific organs or cell types provides an entry point for understanding biological processes that occur uniquely within a particular tissue. Using a subtraction approach designed to identify genes preferentially expressed in specific tissues, we have identified prostase, a human serine protease with prostate-restricted expression. The prostase cDNA encodes a putative 254-aa polypeptide with a conserved serine protease catalytic triad and an amino-terminal pre-propeptide sequence, indicating a potential secretory function. The genomic sequence comprises five exons and four introns and contains multiple copies of a chromosome 19q-specific minisatellite repeat. Northern analysis indicates that prostase mRNA is expressed in hormonally responsive normal and neoplastic prostate epithelial tissues, but not in prostate stromal constituents. Prostase shares 35% amino acid identity with prostate-specific antigen (PSA) and 78% identity with the porcine enamel matrix serine proteinase 1, an enzyme involved in enamel matrix degradation and with a putative role in the disruption of intercellular junctions. Radiation-hybrid-panel mapping localized prostase to chromosome 19q13, a region containing several other serine proteases, including protease M, pancreatic/renal kallikrein hK1, and the prostate-specific kallikreins hK2 and hK3 (PSA). The sequence homology between prostase and other well-characterized serine proteases suggests several potential functional roles for the prostase protein that include the degradation of extracellular matrix and the activation of PSA and other proteases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.