ArticleProceedings of the National Academy of Sciences of the United States of America1999
Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 52 citations in OpenAlex.
- Divergent evolution of low-complexity regions in the vertebrate CPEB protein family.Frontiers in bioinformatics · 2025Article
- Madurella mycetomatis grains within a eumycetoma lesion are clonal.Medical mycology · 2022Article
- PolypeptideMolecules (Basel, Switzerland) · 2021Review
- Compound Dynamics and Combinatorial Patterns of Amino Acid Repeats Encode a System of Evolutionary and Developmental Markers.Genome biology and evolution · 2019Article
- Review
- Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.Glycobiology · 2012Review
- Functional and physical interaction between the mismatch repair and FA-BRCA pathways.Human molecular genetics · 2011Article
- Rescue of Drosophila Melanogaster l(2)35Aa lethality is only mediated by polypeptide GalNAc-transferase pgant35A, but not by the evolutionary conserved human ortholog GalNAc-transferase-T11.Glycoconjugate journal · 2010Article
- Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae.Current biology : CB · 2010Article
- Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences.Nucleic acids research · 2008Article
- Meiotic recombination in Drosophila Msh6 mutants yields discontinuous gene conversion tracts.Genetics · 2007Article
- Multiple-pathway analysis of double-strand break repair mutations in Drosophila.PLoS genetics · 2007Article
- MSH2 is essential for the preservation of genome integrity and prevents homeologous recombination in the moss Physcomitrella patens.Nucleic acids research · 2006Article
- Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus.The Biochemical journal · 2004Article
- Article
- Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- DNA repair in Drosophila: insights from the Drosophila genome sequence.The Journal of cell biology · 2000Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have cloned a mutS homolog from Drosophila melanogaster called spellchecker1 (spel1) and have constructed spel1 mutant flies. MutS proteins promote the correction of DNA mismatches and serve important roles in DNA replication, recombination, and repair. The spel1 gene belongs to a subfamily of mutS first characterized by the MSH2 gene of yeast and which also includes hMSH2, one of the two major hereditary nonpolyposis colon cancer loci of humans. Like msh2 mutants in other species, we find that flies lacking the spel1 gene suffer a highly increased rate of instability in long runs of dinucleotide repeats when analyzed after 10-12 fly generations. Using a new assay, we have also discovered that mutations in spel1 decrease the stability of a dinucleotide repeat when it is copied into the site of a double-strand break during gene conversion. Contrary to the case in mammalian cells, spel1 deficiency does not affect tolerance of flies to a methylating agent nor does it affect resistance to gamma-irradiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.