ArticleProceedings of the National Academy of Sciences of the United States of America1999
Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 193 citations in OpenAlex.
- A new MYH2 variant in an Italian patient expanding the clinical spectrum of MYH2-related myopathy.BMC neurology · 2026Article
- A song of heads and tails: myosin II conformational regulation and filament dynamics shape force generation in non-muscle cells.Biophysical reviews · 2026Review
- Expression of MyHC-15 and -2x in human muscle spindles: An immunohistochemical study.Journal of anatomy · 2023Article
- Distinct and shared endothermic strategies in the heat producing tissues of tuna and other teleosts.Science China. Life sciences · 2023Article
- Roles of Skeletal Muscle in Development: A Bioinformatics and Systems Biology Overview.Advances in anatomy, embryology, and cell biology · 2023Article
- A mitofusin 2/HIF1α axis sets a maturation checkpoint in regenerating skeletal muscle.The Journal of clinical investigation · 2022Article
- Novel Deep Eutectic Solvent-Based Protein Extraction Method for Pottery Residues and Archeological Implications.Journal of proteome research · 2022Article
- New Insights into the Diversity of Branchiomeric Muscle Development: Genetic Programs and Differentiation.Biology · 2022Review
- Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle.Communications biology · 2021Article
- Regulation of the Expression of the Myosin Heavy Chain (MYH) Gene myh14 in Zebrafish Development.Marine biotechnology (New York, N.Y.) · 2021Article
- A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Combination of cell signaling molecules can facilitate MYOD1-mediated myogenic transdifferentiation of pig fibroblasts.Journal of animal science and biotechnology · 2021Article
- MRI-Based Assessment of Masticatory Muscle Changes in TMD Patients after Whiplash Injury.Journal of clinical medicine · 2021Article
- Function and Fiber-Type Specific Distribution of Hsp60 and αB-Crystallin in Skeletal Muscles: Role of Physical Exercise.Biology · 2021Review
- The Effect of Mechanical Stretch on Myotube Growth Suppression by Colon-26 Tumor-Derived Factors.Frontiers in cell and developmental biology · 2021Article
- Regulation of myosin heavy chain antisense long noncoding RNA in human vastus lateralis in response to exercise training.American journal of physiology. Cell physiology · 2020Article
- Myosin heavy chain-embryonic regulates skeletal muscle differentiation during mammalian development.Development (Cambridge, England) · 2020Article
- Novel potential causative genes in carotid paragangliomas.BMC medical genetics · 2019Article
- Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals.Comprehensive Physiology · 2019Review
- The ancient sarcomeric myosins found in specialized muscles.Skeletal muscle · 2019Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Myosin heavy chains (MyHCs) are highly conserved ubiquitous actin-based motor proteins that drive a wide range of motile processes in eukaryotic cells. MyHC isoforms expressed in skeletal muscles are encoded by a multigene family that is clustered on syntenic regions of human and mouse chromosomes 17 and 11, respectively. In an effort to gain a better understanding of the genomic organization of the skeletal MyHC genes and its effects on the regulation, function, and molecular genetics of this multigene family, we have constructed high-resolution physical maps of both human and mouse loci using PCR-based marker content mapping of P1-artificial chromosome clones. Genes encoding six MyHC isoforms have been mapped with respect to their linear order and transcriptional orientations within a 350-kb region in both human and mouse. These maps reveal that the order, transcriptional orientation, and relative intergenic distances of these genes are remarkably conserved between these species. Unlike many clustered gene families, this order does not reflect the known temporal expression patterns of these genes. However, the conservation of gene organization since the estimated divergence of these species (approximately 75-110 million years ago) suggests that the physical organization of these genes may be significant for their regulation and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.