ArticleProceedings of the National Academy of Sciences of the United States of America1999
Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 109 citations in OpenAlex.
- Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.Nature genetics · 2025Article
- Review
- Review
- Impact of Genetics on Mature Lymphoid Leukemias and Lymphomas.Cold Spring Harbor perspectives in medicine · 2020Review
- The TCL1 function revisited focusing on metabolic requirements of stemness.Cell cycle (Georgetown, Tex.) · 2019Review
- Review
- Mature T-cell leukemias: Molecular and Clinical Aspects.Current hematologic malignancy reports · 2015Review
- Integrated genomic sequencing reveals mutational landscape of T-cell prolymphocytic leukemia.Blood · 2014Article
- Tcrδ translocations that delete the Bcl11b haploinsufficient tumor suppressor gene promote atm-deficient T cell acute lymphoblastic leukemia.Cell cycle (Georgetown, Tex.) · 2014Article
- Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Oncogenesis · 2013Article
- Article
- T-cell prolymphocytic leukemia.Proceedings (Baylor University. Medical Center) · 2013Article
- Pediatric T-cell prolymphocytic leukemia with an isolated 12(p13) deletion and aberrant CD117 expression.Experimental hematology & oncology · 2012Article
- Article
- TCL1A gene involvement in T-cell prolymphocytic leukemia in Japanese patients.International journal of hematology · 2012Article
- Accurate molecular classification of cancer using simple rules.BMC medical genomics · 2009Article
- Recurrent translocations involving the IRF4 oncogene locus in peripheral T-cell lymphomas.Leukemia · 2009Article
- Detection of Epstein-Barr virus in T-cell prolymphocytic leukemia cells in vitro.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2008Article
- [Value of targeted treatment for testicular cancer: from molecular approaches to clinical possibilities].Der Urologe. Ausg. A · 2008Review
- Incidence of TCR and TCL1 gene translocations and isochromosome 7q in peripheral T-cell lymphomas using fluorescence in situ hybridization.American journal of clinical pathology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.