ArticleProceedings of the National Academy of Sciences of the United States of America1999
Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
74 citing papers in PubMed.
- Resequencing and De Novo Assembly ofPathogens (Basel, Switzerland) · 2026Article
- Article
- Evolutionary divergent clusters of transcribed extinct truncated retroposons drive low mRNA expression and developmental regulation in the protozoan Leishmania.BMC biology · 2024Article
- Leishmania major-induced alteration of host cellular and systemic copper homeostasis drives the fate of infection.Communications biology · 2024Article
- Modulation of Virulence Factors duringPathogens (Basel, Switzerland) · 2022Review
- Making the Most of Its Short Reads: A Bioinformatics Workflow for Analysing the Short-Read-Only Data ofBiology · 2022Article
- Nucleosome Structures Built from Highly Divergent Histones: Parasites and Giant DNA Viruses.Epigenomes · 2022Review
- Finding Correlations Between mRNA and Protein Levels inFrontiers in cellular and infection microbiology · 2022Review
- A profile of research on the parasitic trypanosomatids and the diseases they cause.PLoS neglected tropical diseases · 2022Review
- Casein kinase 1.2 over expression restores stress resistance to Leishmania donovani HSP23 null mutants.Scientific reports · 2020Article
- Selective human inhibitors of ATR and ATM render Leishmania major promastigotes sensitive to oxidative damage.PloS one · 2018Article
- The Pumilio-domain protein PUF6 contributes to SIDER2 retroposon-mediated mRNA decay inRNA (New York, N.Y.) · 2017Article
- Identification of the centromeres ofEMBO reports · 2017Article
- Chromosomal Translocations in the Parasite Leishmania by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism.PLoS genetics · 2016Article
- Influence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture.PLoS neglected tropical diseases · 2016Article
- Article
- Transcriptomic profiling of gene expression and RNA processing during Leishmania major differentiation.Nucleic acids research · 2015Article
- Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei.BMC genomics · 2014Article
- The transcriptome of Leishmania major in the axenic promastigote stage: transcript annotation and relative expression levels by RNA-seq.BMC genomics · 2013Article
- Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.Cell · 2012Article
14 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors.
Funding
Abstract
Leishmania are evolutionarily ancient protozoans (Kinetoplastidae) and important human pathogens that cause a spectrum of diseases ranging from the asymptomatic to the lethal. The Leishmania genome is relatively small [ approximately 34 megabases (Mb)], lacks substantial repetitive DNA, and is distributed among 36 chromosomes pairs ranging in size from 0.3 Mb to 2.5 Mb, making it a useful candidate for complete genome sequence determination. We report here the nucleotide sequence of the smallest chromosome, chr1. The sequence of chr1 has a 257-kilobase region that is densely packed with 79 protein-coding genes. This region is flanked by telomeric and subtelomeric repetitive elements that vary in number and content among the chr1 homologs, resulting in an approximately 27.5-kilobase size difference. Strikingly, the first 29 genes are all encoded on one DNA strand, whereas the remaining 50 genes are encoded on the opposite strand. Based on the gene density of chr1, we predict a total of approximately 9,800 genes in Leishmania, of which 40% may encode unknown proteins.
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