ArticleBritish journal of pharmacology1999
Neurogenic plasma leakage in mouse airways.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 52 citations in OpenAlex.
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- Bitter taste signaling in tracheal epithelial brush cells elicits innate immune responses to bacterial infection.The Journal of clinical investigation · 2022Article
- Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- β1-Na(+),K(+)-ATPase gene therapy upregulates tight junctions to rescue lipopolysaccharide-induced acute lung injury.Gene therapy · 2016Article
- The Hemagglutinin Stem-Binding Monoclonal Antibody VIS410 Controls Influenza Virus-Induced Acute Respiratory Distress Syndrome.Antimicrobial agents and chemotherapy · 2016Article
- Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2.British journal of pharmacology · 2016Article
- The neuraminidase inhibitor oseltamivir is effective against A/Anhui/1/2013 (H7N9) influenza virus in a mouse model of acute respiratory distress syndrome.The Journal of infectious diseases · 2014Article
- Cholinergic neurotransmission links solitary chemosensory cells to nasal inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation.American journal of respiratory and critical care medicine · 2012Article
- Models of inflammation of the lower urinary tract.Neurourology and urodynamics · 2011Review
- A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation.British journal of pharmacology · 2010Article
- Pulmonary inflammation triggered by ricin toxin requires macrophages and IL-1 signaling.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Urotensin II stimulates plasma extravasation in mice via UT receptor activation.Naunyn-Schmiedeberg's archives of pharmacology · 2004Article
- Cellular and molecular mechanisms in environmental and occupational inhalation toxicology.GMS current topics in otorhinolaryngology, head and neck surgery · 2004Article
- Hypersensitivity reactions in mouse airways after a single and a repeated hapten challenge.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2002Article
- Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation.The American journal of pathology · 2001Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
1. This study sought to determine whether neurogenic inflammation occurs in the airways by examining the effects of capsaicin or substance P on microvascular plasma leakage in the trachea and lungs of male pathogen-free C57BL/6 mice. 2. Single bolus intravenous injections of capsaicin (0.5 and 1 micromol kg(-1), i.v.) or substance P (1, 10 and 37 nmol kg(-10, i.v.) failed to induce significant leakage in the trachea, assessed as extravasation of Evans blue dye, but did induce leakage in the urinary bladder and skin. 3. Pretreatment with captopril (2.5 mg kg(-1), i.v.), a selective inhibitor of angiotensin converting enzyme (ACE), either alone or in combination with phosphoramidon (2.5 mg kg(-1), i.v.), a selective inhibitor of neutral endopeptidase (NEP), increased baseline leakage of Evans blue in the absence of any exogenous inflammatory mediator. The increase was reversed by the bradykinin B2 receptor antagonist Hoe 140 (0.1 mg kg(-1), i.v.). 4. After pretreatment with phosphoramidon and captopril, capsaicin increased the Evans blue leakage above the baseline in the trachea, but not in the lung. This increase was reversed by the tachykinin (NK1) receptor antagonist SR 140333 (0.7 mg kg(-1), i.v.), but not by the NK2 receptor antagonist SR 48968 (1 mg kg(-1), i.v.). 5. Experiments using Monastral blue pigment as a tracer localized the leakage to postcapillary venules in the trachea and intrapulmonary bronchi, although the labelled vessels were less numerous in mice than in comparably treated rats. Blood vessels of the pulmonary circulation were not labelled. 6. We conclude that neurogenic inflammation can occur in airways of pathogen-free mice, but only after the inhibition of enzymes that normally degrade inflammatory peptides. Neurogenic inflammation does not involve the pulmonary microvasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.