ArticleThe Journal of experimental medicine1999
Regulation of interleukin (IL)-12 receptor beta2 subunit expression by endogenous IL-12: a critical step in the differentiation of pathogenic autoreactive T cells.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 101 citations in OpenAlex.
- An immunomodulating peptide with potential to suppress tumour growth and autoimmunity.Scientific reports · 2023Article
- Immune Regulatory Genes Are Major Genetic Factors to Behcet Disease: Systematic Review.The open rheumatology journal · 2018Review
- The immunogenetics of Behçet's disease: A comprehensive review.Journal of autoimmunity · 2015Review
- Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.Immunology and cell biology · 2015Article
- Article
- Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.The Journal of biological chemistry · 2013Article
- Prostaglandin E₂ promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase.Nature communications · 2013Article
- IL-2 family cytokines: new insights into the complex roles of IL-2 as a broad regulator of T helper cell differentiation.Current opinion in immunology · 2011Review
- Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci.Nature genetics · 2010Article
- Abatacept in difficult-to-treat juvenile idiopathic arthritis.Biologics : targets & therapy · 2008Article
- Article
- A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci.PLoS genetics · 2008Article
- Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Passive or active immunization with myelin basic protein impairs neurological function and exacerbates neuropathology after spinal cord injury in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Genetic analysis of the influence of neuroantigen-complete Freund's adjuvant emulsion structures on the sexual dimorphism and susceptibility to experimental allergic encephalomyelitis.The American journal of pathology · 2003Article
- Functional changes of dendritic cells derived from allogeneic partial liver graft undergoing acute rejection in rats.World journal of gastroenterology · 2003Article
- Cytotoxic T lymphocyte antigen-4 (CTLA-4) limits the expansion of encephalitogenic T cells in experimental autoimmune encephalomyelitis (EAE)-resistant BALB/c mice.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- CD4+CD28- costimulation-independent T cells in multiple sclerosis.The Journal of clinical investigation · 2001Article
- Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis.The Journal of clinical investigation · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The interleukin (IL)-12 receptor (R)beta2 subunit is the critical molecule involved in maintaining IL-12 responsiveness and controlling T helper cell type 1 lineage commitment. We demonstrate that IL-12 and interferon (IFN)-gamma play separate, but complementary, roles in regulating IL-12Rbeta2 expression on antigen-specific CD4(+) T cells. These results are consistent with our previous observation that IL-12 can promote autoimmune disease through IFN-gamma-independent as well as -dependent pathways. Therefore, we compared the induction of IL-12 by, and the expression of the IL-12Rbeta2 subunit on, myelin basic protein (MBP)-specific T cells from experimental allergic encephalomyelitis (EAE)-susceptible SJL (H-2(s)) mice and from EAE- resistant B10.S mice (H-2(s)). B10.S mice had an antigen-specific defect in their capacity to upregulate the IL-12Rbeta2 subunit. Defective expression was not secondary to the production of suppressive cytokines, but to a failure of B10.S MBP-specific T cells to upregulate CD40 ligand expression and to induce the production of IL-12. IL-12Rbeta2 expression as well as encephalitogenicity of these cells could be restored by the addition of IL-12. These results suggest that the development of immunotherapies that target the IL-12Rbeta2 subunit may be useful for the treatment of autoimmune diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.