ArticleGut1999
Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses.
Article in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 113 citations in OpenAlex.
- Pharmacogenetic investigation of the TNF/TNF-receptor system in patients with chronic active Crohn's disease treated with infliximab.The pharmacogenomics journal · 2002Trial
- The association between psoriasis, psoriasis severity, and inflammatory bowel disease: a population-based analysis.Therapeutic advances in gastroenterology · 2024Article
- Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity.International journal of molecular sciences · 2021Review
- Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis.Yonago acta medica · 2018Article
- Digestive system in psoriasis: an update.Archives of dermatological research · 2017Review
- Psoriasis and inflammatory bowel disease: links and risks.Psoriasis (Auckland, N.Z.) · 2016Review
- Matrix metalloproteinases in inflammatory bowel disease: an update.Mediators of inflammation · 2015Review
- Genetic update on inflammatory factors in ulcerative colitis: Review of the current literature.World journal of gastrointestinal pathophysiology · 2014Review
- Correlations between psoriasis and inflammatory bowel diseases.BioMed research international · 2013Review
- Genetic association of nonsynonymous variants of the IL23R with familial and sporadic inflammatory bowel disease in women.Digestive diseases and sciences · 2010Article
- Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis.Experimental & molecular medicine · 2010Article
- Role of matrix metalloproteinase, tissue inhibitor of metalloproteinase and tumor necrosis factor-alpha single nucleotide gene polymorphisms in inflammatory bowel disease.World journal of gastroenterology · 2007Article
- Genetics of inflammatory bowel disease: current status and future directions.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Review
- Genetics of inflammatory bowel disease: the role of the HLA complex.World journal of gastroenterology · 2006Review
- Genotype and phenotype relation in inflammatory bowel disease.Journal of gastroenterology · 2005Article
- Recent advances in the diagnosis and classification of inflammatory bowel disease.Current gastroenterology reports · 2003Review
- Stratification by CARD15 variant genotype in a genome-wide search for inflammatory bowel disease susceptibility loci.Human genetics · 2003Article
- Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning.World journal of gastroenterology · 2003Review
- Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.Clinical and experimental immunology · 2003Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is evidence for genetic susceptibility to Crohn's disease, and a tentative association with tumour necrosis factor (TNF) and HLA class II alleles.
aimsTo examine the potential of genetic linkage between Crohn's disease and the MHC region on chromosome 6p.
methodsTNF microsatellite markers and, for some families, additional HLA antigens were typed for 323 individuals from 49 Crohn's disease multiplex families to generate informative haplotypes. Non-parametric linkage analysis methods, including sib pair and affected relative pair methods, were used.
resultsIncreased sharing of haplotypes was observed in affected sib pairs: 92% (48/52) shared one or two haplotypes versus an expected 75% if linkage did not exist (p=0.004). After other affected relative pairs were included, the significance level reached 0.001. The mean proportion of haplotype sharing was increased for both concordant affected (pi=0.60, p=0.002) and unaffected sib pairs (pi=0.58, p=0. 031) compared with the expected value (pi=0.5). In contrast, sharing in discordant sib pairs was significantly decreased (pi=0.42, p=0. 007). Linear regression analysis using all three types of sib pairs yielded a slope of -0.38 at p=0.00003. It seemed that the HLA effect was stronger in non-Jewish families than in Jewish families.
conclusionsAll available analytical methods support linkage of Crohn's disease to the MHC region in these Crohn's disease families. This region is estimated to contribute approximately 10-33% of the total genetic risk to Crohn's disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.