ArticleGut1999
Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole.
Article in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Relative potency of proton-pump inhibitors-comparison of effects on intragastric pH.European journal of clinical pharmacology · 2009Pooled it
- Pharmacokinetics and Pharmacodynamics of YYD601, a Dual Delayed-Release Formulation of Esomeprazole, Following Single and Multiple Doses in Healthy Adult Volunteers Under Fasting and Fed Conditions.Drug design, development and therapy · 2022Trial
- A study on the efficacy of rebamipide for patients with proton pump inhibitor-refractory non-erosive reflux disease.Digestive diseases and sciences · 2012Trial
- Dose-response relationships of rabeprazole 5, 10, 20, and 40 mg once daily on suppression of gastric acid secretion through the night in healthy Japanese individuals with different CYP2C19 genotypes.European journal of clinical pharmacology · 2012Trial
- Comparison of PPIs and H2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia.World journal of gastroenterology · 2012Trial
- Randomized, parallel, double-blind comparison of the ulcer-healing effects of ilaprazole and omeprazole in the treatment of gastric and duodenal ulcers.Journal of gastroenterology · 2009Trial
- Acid-suppressive efficacy of a reduced dosage of rabeprazole: comparison of 10 mg twice daily rabeprazole with 20 mg twice daily rabeprazole, 30 mg twice daily lansoprazole, and 20 mg twice daily omeprazole by 24-hr intragastric pH-metry.Digestive diseases and sciences · 2005Trial
- Trial
- Potential Efficacy of Propolis in TreatingNutrients · 2025Review
- Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence.Therapeutic advances in gastroenterology · 2019Review
- A systematic approach for the diagnosis and treatment of idiopathic peptic ulcers.The Korean journal of internal medicine · 2015Review
- Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4).Annals of oncology : official journal of the European Society for Medical Oncology · 2013Article
- High Recurrence Rate of Idiopathic Peptic Ulcers in Long-Term Follow-up.Gut and liver · 2013Article
- Quality measures for medication continuity in long-term care facilities, using a structured panel process.Drugs & aging · 2012Article
- Validation of the blood quininium resin test for assessing gastric hypochlorhydria.Digestive diseases and sciences · 2006Article
- The effect of intragastric ammonia production on titratable gastric acid output in Helicobacter pylori-infected patients with chronic gastritis.Digestive diseases and sciences · 2005Article
- Helicobacter pylori infection in patients with erosive esophagitis is associated with rapid heartburn relief and lack of relapse after treatment with pantoprazole.Digestive diseases and sciences · 2005Article
- NSAID-induced peptic ulcers and Helicobacter pylori infection: implications for patient management.Drug safety · 2005Review
- Inhibitory potency of twice-a-day omeprazole on gastric acidity is enhanced by eradication of H. pylori in duodenal ulcer patients.Digestive diseases and sciences · 2003Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOmeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism.
aimsTo assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased omeprazole efficacy in infected subjects.
methodsTwenty H pylori positive and 12 H pylori negative healthy volunteers were examined before and six to eight weeks after commencing omeprazole 40 mg/day. On both occasions plasma gastrin and acid output were measured basally and in response to increasing doses of gastrin 17 (G-17). Gastric juice ammonium concentrations were also measured.
resultsPrior to omeprazole, measurements were similar in the H pylori positive and negative subjects. During omeprazole, median basal intragastric pH was higher in the H pylori positive (7.95) versus negative (3.75) subjects (p<0.002). During omeprazole basal, submaximal (180 pmol/kg/h G-17), and maximal acid outputs (800 pmol/kg/h G-17) were lower in H pylori positive subjects (0.0, 3.6, 6.0 mmol/h respectively) versus negative subjects (0.3, 14.2, 18.6 mmol/h) (p<0.03 for each). This effect was not explained by neutralisation by ammonia.
conclusionThe presence of H pylori infection leads to a more profound suppression of acid secretion during omeprazole treatment. The effect cannot be explained by neutralisation of intragastric acid by bacterial ammonia production and its precise mechanism has to be explained.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.