ArticleThe EMBO journal1999
Intronless mRNA transport elements may affect multiple steps of pre-mRNA processing.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed.
- A common structural mechanism for RNA recognition by the SF3B complex in mRNA splicing and export.Nucleic acids research · 2025Article
- Genome-Wide CRISPR Screening to Identify Mammalian Factors that Regulate Intron Retention.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.Retrovirology · 2014Article
- A novel RNA motif mediates the strict nuclear localization of a long noncoding RNA.Molecular and cellular biology · 2014Article
- Depletion of hnRNP A2/B1 overrides the nuclear retention of the HIV-1 genomic RNA.RNA biology · 2013Article
- Expression of Hsp70 in the mud crab, Scylla paramamosain in response to bacterial, osmotic, and thermal stress.Cell stress & chaperones · 2013Article
- Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.Molecular biology of the cell · 2013Article
- Evidence that a consensus element found in naturally intronless mRNAs promotes mRNA export.Nucleic acids research · 2013Article
- Epstein-Barr virus protein EB2 stimulates cytoplasmic mRNA accumulation by counteracting the deleterious effects of SRp20 on viral mRNAs.Nucleic acids research · 2012Article
- Export and stability of naturally intronless mRNAs require specific coding region sequences and the TREX mRNA export complex.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element.Nucleic acids research · 2009Article
- Where do introns come from?PLoS biology · 2008Article
- ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56.Molecular and cellular biology · 2008Article
- U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation.Molecular cell · 2007Article
- Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export.Journal of virology · 2007Article
- The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors.Gene therapy · 2007Article
- Two G-rich regulatory elements located adjacent to and 440 nucleotides downstream of the core poly(A) site of the intronless melanocortin receptor 1 gene are critical for efficient 3' end processing.Molecular and cellular biology · 2007Article
- Nucleophosmin is selectively deposited on mRNA during polyadenylation.Nature structural & molecular biology · 2006Article
- The hepatitis B virus PRE contains a splicing regulatory element.Nucleic acids research · 2006Article
- Epstein-Barr virus mRNA export factor EB2 is essential for intranuclear capsid assembly and production of gp350.Journal of virology · 2005Article
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Authors and funding
3 authors.
Funding
Abstract
We have reported recently that a small element within the mouse histone H2a-coding region permits efficient cytoplasmic accumulation of intronless beta-globin cDNA transcripts. This sequence lowers the levels of spliced products from intron-containing constructs and can functionally replace Rev and the Rev-responsive element (RRE) in the nuclear export of unspliced HIV-1-related mRNAs. In work reported here, we further investigate the molecular mechanisms by which this element might work. We demonstrate here through both in vivo and in vitro assays that, in addition to promoting mRNA nuclear export, this element acts as a polyadenylation enhancer and as a potent inhibitor of splicing. Surprisingly, two other described intronless mRNA transport elements (from the herpes simplex virus thymidine kinase gene and hepatitis B virus) appear to function in a similar manner. These findings prompt us to suggest that a general feature of intronless mRNA transport elements might be a collection of phenotypes, including the inhibition of splicing and the enhancement of both polyadenylation and mRNA export.
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