ArticleJournal of clinical microbiology1999
Detection of Epstein-Barr virus DNA in sera from transplant recipients with lymphoproliferative disorders.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Intensive postgrafting immune suppression combined with nonmyeloablative conditioning for transplantation of HLA-identical hematopoietic cell grafts: results of a pilot study for treatment of primary immunodeficiency disorders.Bone marrow transplantation · 2007Trial
- Epstein-Barr virus-associated posttransplantation lymphoproliferative disorder after high-dose immunosuppressive therapy and autologous CD34-selected hematopoietic stem cell transplantation for severe autoimmune diseases.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2003Trial
- Playing both sides - Epstein-Barr Virus accumulates select cellular transcripts to counter virus-mediated host shut-off in lytic cells.PLoS pathogens · 2026Article
- [Chinese consensus on the diagnosis and management of Epstein-Barr virus-related post-transplant lymphoproliferative disorders after hematopoietic stem cell transplantation (2022)].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2022Article
- Targeting an alternate Wilms' tumor antigen 1 peptide bypasses immunoproteasome dependency.Science translational medicine · 2022Article
- T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant.Nature medicine · 2019Article
- Isolation of a novel chronic lymphocytic leukemic (CLL) cell line and development of an in vivo mouse model of CLL.Leukemia research · 2016Article
- Molecular monitoring of viral infections after hematopoietic stem cell transplantation.International journal of hematology · 2010Review
- Development of multiplexed real-time quantitative polymerase chain reaction assay for detecting human adenoviruses.Diagnostic microbiology and infectious disease · 2008Article
- Cytomegalovirus and Epstein-Barr virus in breast milk are associated with HIV-1 shedding but not with mastitis.AIDS (London, England) · 2008Article
- Comparison of various blood compartments and reporting units for the detection and quantification of Epstein-Barr virus in peripheral blood.Journal of clinical microbiology · 2007Article
- Detection of free circulating Epstein-Barr virus DNA in plasma of patients with Hodgkin's disease.Sao Paulo medical journal = Revista paulista de medicina · 2006Article
- Post-transplant lymphoproliferative disorder in children: incidence, prognosis, and treatment options.Paediatric drugs · 2005Review
- Surface immunoglobulin-deficient Epstein-Barr virus-infected B cells in the peripheral blood of pediatric solid-organ transplant recipients.Journal of clinical microbiology · 2004Article
- Measurement of Epstein-Barr virus DNA loads in whole blood and plasma by TaqMan PCR and in peripheral blood lymphocytes by competitive PCR.Journal of clinical microbiology · 2003Article
- Herpesvirus infections in organ transplant recipients.Clinical and diagnostic laboratory immunology · 2003Review
- Epstein-Barr virus DNA load in cerebrospinal fluid and plasma of patients with AIDS-related lymphoma.Journal of neurovirology · 2002Article
- Molecular Techniques in the Diagnosis of Central Nervous System Infections.Current infectious disease reports · 2002Article
- Detection of Epstein-Barr virus genomes in peripheral blood B cells from solid-organ transplant recipients by fluorescence in situ hybridization.Journal of clinical microbiology · 2002Article
- Central nervous system infection during immunosuppression.Neurologic clinics · 2002Review
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early diagnosis of Epstein-Barr Virus (EBV)-associated posttransplant lymphoproliferative disease (PTLD) is important because many patients respond to reduction in immunosuppression, especially if PTLD is detected at an early stage. Previous studies have found elevated EBV DNA levels in blood from patients with PTLD, but these assays required isolation of cellular blood fractions and quantitation. We evaluated the presence of cell-free EBV DNA in serum from solid-organ transplant recipients as a marker for PTLD. Five of 6 transplant recipients with histopathologically documented PTLD had EBV DNA detected in serum at the time of diagnosis (sensitivity = 83%), compared with 0 of 16 matched transplant recipients without PTLD (specificity = 100%) (P < 0.001 [Fisher's exact test]). Furthermore, EBV DNA was detected in serum 8 and 52 months prior to the diagnosis of PTLD in two of three patients for whom stored sera were analyzed. Detection of EBV DNA in serum appears to be a useful marker for the early detection of PTLD in solid-organ transplant recipients. Further studies to define the role of such assays in evaluating solid-organ transplant patients at risk for PTLD are warranted.
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