ArticleThe Journal of clinical investigation1999
P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 122 citations in OpenAlex.
- Erythroid Atypical Chemokine Receptor 1 Deficiency Aggravates Immune-Mediated Kidney Disease.Journal of the American Society of Nephrology : JASN · 2026Article
- Glucocorticoids target the CXCL9/CXCL10-CXCR3 axis and confer protection against immune-mediated kidney injury.JCI insight · 2023Article
- Article
- Relevance of PSGL-1 Expression in B Cell Development and Activation.Frontiers in immunology · 2020Article
- Re-Examining Neutrophil Participation in GN.Journal of the American Society of Nephrology : JASN · 2017Review
- Innate and adaptive immunity in experimental glomerulonephritis: a pathfinder tale.Pediatric nephrology (Berlin, Germany) · 2017Review
- P-Selectin preserves immune tolerance in mice and is reduced in human cutaneous lupus.Scientific reports · 2017Article
- Article
- The Spleen Plays No Role in Nephrotoxic Serum Nephritis, but Constitutes a Place of Compensatory Haematopoiesis.PloS one · 2015Article
- Lipocalin-2 expressed in innate immune cells is an endogenous inhibitor of inflammation in murine nephrotoxic serum nephritis.PloS one · 2013Article
- Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis.Immunity · 2012Article
- Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Receptor cleavage and P-selectin-dependent reduction of leukocyte adhesion in the spontaneously hypertensive rat.Journal of leukocyte biology · 2012Article
- Increased renal versican expression is associated with progression of chronic kidney disease.PloS one · 2012Article
- Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy.Diabetes · 2011Article
- The selective mineralocorticoid receptor antagonist eplerenone is protective in mild anti-GBM glomeru-lonephritis.International journal of clinical and experimental pathology · 2011Article
- A murine model of phosphate nephropathy.The American journal of pathology · 2011Article
- IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.The American journal of pathology · 2010Article
- Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
P-selectin is a leukocyte adhesion receptor present in endothelial cells and platelets. We examined the role of P-selectin in the autologous phase of an accelerated model of anti-glomerular basement membrane (GBM) glomerulonephritis using P-selectin-deficient mice and chimeric mice expressing P-selectin only in platelets or endothelial cells. P-selectin-deficient mice exhibited more severe glomerular damage with increased interstitial mononuclear leukocytic infiltrates, and had significantly increased proteinuria and mortality when compared to wild-type mice. P-selectin on the endothelium was predominantly responsible for protection from the exacerbated disease, because chimeric mice with endothelial P-selectin, and not mice with platelet P-selectin, showed glomerular injury similar to that in wild-type animals. Levels of soluble circulating P-selectin were increased in nephritic wild-type mice and in chimeric mice with endothelial P-selectin, but not platelet P-selectin. Levels of soluble P-selectin, which has been shown to be anti-inflammatory in vitro, were inversely associated with the severity of disease. P-selectin was not expressed in the endothelium of the glomerulus or interstitium. Thus, the protective effect in wild-type mice may be accounted for, in part by soluble P-selectin shed by non-renal endothelial cells, although other endothelial P-selectin-dependent mechanisms cannot be ruled out.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.