ArticleJournal of virology1999
Dissecting the role of the N-terminal domain of human immunodeficiency virus integrase by trans-complementation analysis.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Going beyond Integration: The Emerging Role of HIV-1 Integrase in Virion Morphogenesis.Viruses · 2020Review
- Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration.Nucleic acids research · 2019Article
- Different Pathways Leading to Integrase Inhibitors Resistance.Frontiers in microbiology · 2016Review
- HIV-1 integrase multimerization as a therapeutic target.Current topics in microbiology and immunology · 2015Review
- Biochemical characteristics of functional domains using feline foamy virus integrase mutants.BMB reports · 2013Article
- A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication.PloS one · 2012Article
- Review
- A new functional role of HIV-1 integrase during uncoating of the viral core.Immunologic research · 2010Article
- HIV-1 Integrase-DNA Recognition Mechanisms.Viruses · 2009Article
- The Interaction Between Lentiviral Integrase and LEDGF: Structural and Functional Insights.Viruses · 2009Article
- An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule.Molecular pharmacology · 2009Article
- Integrase and integration: biochemical activities of HIV-1 integrase.Retrovirology · 2008Review
- Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding.The Journal of biological chemistry · 2008Article
- Molecular mechanisms by which human immunodeficiency virus type 1 integrase stimulates the early steps of reverse transcription.Journal of virology · 2007Article
- A three-dimensional model of the human immunodeficiency virus type 1 integration complex.Journal of computer-aided molecular design · 2005Article
- HIV-1 integrase crosslinked oligomers are active in vitro.Nucleic acids research · 2005Article
- Differential multimerization of Moloney murine leukemia virus integrase purified under nondenaturing conditions.Virology · 2003Article
- Disulfide-linked integrase oligomers involving C280 residues are formed in vitro and in vivo but are not essential for human immunodeficiency virus replication.Journal of virology · 2003Article
- Assembly and catalysis of concerted two-end integration events by Moloney murine leukemia virus integrase.Journal of virology · 2001Article
- DNA binding induces dissociation of the multimeric form of HIV-1 integrase: a time-resolved fluorescence anisotropy study.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human immunodeficiency virus (HIV) integrase protein (IN) catalyzes two reactions required to integrate HIV DNA into the human genome: 3' processing of the viral DNA ends and integration. IN has three domains, the N-terminal zinc-binding domain, the catalytic core, and the C-terminal SH3 domain. Previously, it was shown that IN proteins mutated in different domains could complement each other. We now report that this does not require any overlap between the two complementing proteins; an N-terminal domain, provided in trans, can restore IN activity of a mutant lacking this domain. Only the zinc-coordinating form of the N-terminal domain can efficiently restore IN activity of an N-terminal deletion mutant. This suggests that interaction between different domains of IN is needed for functional multimerization. We find that the N-terminal domain of feline immunodeficiency virus IN can support IN activity of an N-terminal deletion mutant of HIV type 2 IN. These cross-complementation experiments indicate that the N-terminal domain contributes to the recognition of specific viral DNA ends.
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