ArticleJournal of virology1999
Recombinant duck interferon gamma inhibits duck hepatitis B virus replication in primary hepatocytes.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 90 citations in OpenAlex.
- Duck IFNγ Restricts Duck Tembusu Virus Replication by Disrupting Viral RNA Synthesis/Translation.Veterinary sciences · 2026Article
- Clinical and molecular identification of Newcastle disease virus in naturally infected chicks in Thi-Qar province of Iraq.Open veterinary journal · 2024Article
- Antiviral Effects of Avian Interferon-Stimulated Genes.Animals : an open access journal from MDPI · 2024Review
- Establishment of a hydrodynamic delivery system in ducks.Transgenic research · 2024Article
- IFN-γ establishes interferon-stimulated gene-mediated antiviral state against Newcastle disease virus in chicken fibroblasts.Acta biochimica et biophysica Sinica · 2020Article
- Avian Interferons and Their Antiviral Effectors.Frontiers in immunology · 2017Review
- Immune therapy for hepatitis B.Annals of translational medicine · 2016Review
- Article
- Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen.Scientific reports · 2016Article
- Pre-immune state induced by chicken interferon gamma inhibits the replication of H1N1 human and H9N2 avian influenza viruses in chicken embryo fibroblasts.Virology journal · 2016Article
- Effects of Chicken Interferon Gamma on Newcastle Disease Virus Vaccine Immunogenicity.PloS one · 2016Article
- Molecular biology of hepatitis B virus infection.Virology · 2015Review
- Interferons and their receptors in birds: a comparison of gene structure, phylogenetic analysis, and cross modulation.International journal of molecular sciences · 2014Review
- Is hepatitis B-virucidal validation of biocides possible with the use of surrogates?World journal of gastroenterology · 2014Review
- Protection of hepatocytes from cytotoxic T cell mediated killing by interferon-alpha.PloS one · 2007Article
- Tumor necrosis factor activates a conserved innate antiviral response to hepatitis B virus that destabilizes nucleocapsids and reduces nuclear viral DNA.Journal of virology · 2007Article
- IFN-gamma increases efficiency of DNA vaccine in protecting ducks against infection.World journal of gastroenterology · 2005Article
- Kinetics of phytohemaglutinin-induced IFN-gamma and TNF-alpha expression in peripheral blood mononuclear cells from patients with chronic hepatitis B after liver transplantation.World journal of gastroenterology · 2005Article
- Identification, sequence characterization, and analysis of expression profiles of three novel CC chemokines from domestic duck (Anas platyrhynchos).Immunogenetics · 2005Article
- Superinfection exclusion in duck hepatitis B virus infection is mediated by the large surface antigen.Journal of virology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Interferon gamma (IFN-gamma), which has been cloned in several mammalian species and recently in birds, plays a critical role in modulating immune system function. IFN-gamma and tumor necrosis factor alpha (TNF-alpha) have been shown to be crucial in the pathogenesis of viral hepatitis and in the transient disappearance of hepatitis B virus (HBV) from the liver after adoptive transfer of HBV-specific cytotoxic T lymphocytes into HBV-transgenic mice. Similar studies in the natural animal hosts of related hepadnaviruses have been limited because the corresponding probes and recombinant cytokines were not available. For this reason, we initiated studies to clone and characterize cytokines from the duck, the natural host of the duck hepatitis B virus (DHBV). We describe here the cDNA cloning and initial characterization of the IFN-gamma homologue of ducks (DuIFN-gamma). The DuIFN-gamma cDNA codes for a predicted mature protein of 145 amino acids with a molecular mass of 16.6 kDa. The precursor protein has 67% identity with the previously cloned chicken IFN-gamma and 21 to 34% identity with mammalian IFN-gamma. Recombinant DuIFN-gamma induces the transcription of several IFN-inducible genes including IFN regulatory factor 1 and guanylate-binding protein, and it exhibits antiviral activity that protects duck cells from vesicular stomatitis virus-mediated lysis. Importantly, treatment of primary duck hepatocytes with recombinant DuIFN-gamma inhibits DHBV replication in a dose-dependent fashion. Time course analysis revealed that IFN-gamma treatment does not affect initial covalently closed circular DNA (cccDNA) conversion but inhibits the synthesis of progeny cccDNA by amplification.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.