ArticleThe Plant cell1999
Discrete domains mediate the light-responsive nuclear and cytoplasmic localization of Arabidopsis COP1.
Article in The Plant cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 138 citations in OpenAlex.
- One-step selection of high-affinity COP1 aptamers.aBIOTECH · 2026Article
- The Long Intergenic Noncoding RNAPlants (Basel, Switzerland) · 2026Article
- Prolonged light exposure time enhances the photosynthetic investment in osmotrophicApplied and environmental microbiology · 2025Article
- From the archives: evolutionary origins of Delphinieae flowers, pseudogenes, and the light-responsive localization of COP1.The Plant cell · 2024Article
- HOS15 represses flowering by promoting GIGANTEA degradation in response to low temperature in Arabidopsis.Plant communications · 2023Article
- Light Regulation of LoCOP1 and Its Role in Floral Scent Biosynthesis inPlants (Basel, Switzerland) · 2023Article
- Mechanisms of UV-B light-induced photoreceptor UVR8 nuclear localization dynamics.The New phytologist · 2022Article
- CONSTITUTIVE PHOTOMORPHOGENIC 1 promotes seed germination by destabilizing RGA-LIKE 2 in Arabidopsis.Plant physiology · 2022Article
- Abscisic acid-induced cytoplasmic translocation of constitutive photomorphogenic 1 enhances reactive oxygen species accumulation through the HY5-ABI5 pathway to modulate seed germination.Plant, cell & environment · 2022Article
- Constitutive Photomorphogenic 1 Enhances ER Stress Tolerance in Arabidopsis.International journal of molecular sciences · 2021Article
- OsCOP1 regulates embryo development and flavonoid biosynthesis in rice (Oryza sativa L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Illuminating the COP1/SPA Ubiquitin Ligase: Fresh Insights Into Its Structure and Functions During Plant Photomorphogenesis.Frontiers in plant science · 2021Review
- B-box transcription factor 28 regulates flowering by interacting with constans.Scientific reports · 2020Article
- Efficient Plant Production of Recombinant NS1 Protein for Diagnosis of Dengue.Frontiers in plant science · 2020Article
- Plant photoreceptors: Multi-functional sensory proteins and their signaling networks.Seminars in cell & developmental biology · 2019Review
- The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.The EMBO journal · 2019Article
- The SUMO Conjugation Complex Self-Assembles into Nuclear Bodies Independent of SIZ1 and COP1.Plant physiology · 2019Article
- Transcriptome profiling of genes related to light-induced anthocyanin biosynthesis in eggplant (Solanum melongena L.) before purple color becomes evident.BMC genomics · 2018Article
- The F-box protein FKF1 inhibits dimerization of COP1 in the control of photoperiodic flowering.Nature communications · 2017Article
- COP1 mediates dark-specific degradation of microtubule-associated protein WDL3 in regulatingProceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) protein plays a critical role in the repression of photomorphogenesis during Arabidopsis seedling development. We investigated the control of COP1 partitioning between nucleus and cytoplasm, which has been implicated in the regulation of COP1 activity, by using fusion proteins between COP1 and beta-glucuronidase or the green fluorescent protein. Transient expression assays using onion epidermal cells and data from hypocotyl cells of stably transformed Arabidopsis demonstrated that COP1 carries a single, bipartite nuclear localization signal that functions independently of light. Nuclear exclusion was mediated by a novel and distinct signal, bordering the zinc-finger and coiled-coil motifs, that was able to redirect a heterologous nuclear protein to the cytoplasm. The cytoplasmic localization signal functioned in a light-independent manner. Light regulation of nuclear localization was reconstituted by combining the individual domains containing the nuclear localization signal and the cytoplasmic localization signal; the WD-40 repeat domain of COP1 was not required. However, phenotypic analysis of transgenic seedlings suggested that the constitutively nuclear-localized WD-40 repeat domain was able to mimic aspects of COP1 function, as indicated by exaggerated hypocotyl elongation under light conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.