ArticleGenes & development1999
Mos positively regulates Xe-Wee1 to lengthen the first mitotic cell cycle of Xenopus.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Changes in oscillatory dynamics in the cell cycle of early Xenopus laevis embryos.PLoS biology · 2014Article
- Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2.Biochimica et biophysica acta · 2013Article
- Modulation of cell cycle control during oocyte-to-embryo transitions.The EMBO journal · 2013Review
- Identification of a Wee1-like kinase gene essential for procyclic Trypanosoma brucei survival.PloS one · 2013Article
- Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation.Developmental biology · 2012Article
- Developmental timing of mRNA translation--integration of distinct regulatory elements.Molecular reproduction and development · 2010Review
- Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity.Current biology : CB · 2009Article
- Cdc25 and Wee1: analogous opposites?Cell division · 2007Article
- Multisite M-phase phosphorylation of Xenopus Wee1A.Molecular and cellular biology · 2005Article
- Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis.Molecular and cellular biology · 2002Article
- Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.Molecular and cellular biology · 2002Article
- Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts.The Journal of cell biology · 2000Article
- Residual Cdc2 activity remaining at meiosis I exit is essential for meiotic M-M transition in Xenopus oocyte extracts.The EMBO journal · 2000Article
- Activation of Wee1 by p42 MAPK in vitro and in cycling xenopus egg extracts.Molecular biology of the cell · 2000Article
- Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.Genes & development · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several key developmental events occur in the first mitotic cell cycle of Xenopus; consequently this cycle has two gap phases and is approximately 60-75 min in length. In contrast, embryonic cycles 2-12 consist only of S and M phases and are 30 min in length. Xe-Wee1 and Mos are translated and degraded in a developmentally regulated manner. Significantly, both proteins are present in the first cell cycle. We showed previously that the expression of nondegradable Mos, during early interphase, delays the onset of M phase in the early embryonic cell cycles. Here we report that Xe-Wee1 is required for the Mos-mediated M-phase delay. We find that Xe-Wee1 tyrosine autophosphorylation positively regulates Xe-Wee1 and is only detected in the first 30 min of the first cell cycle. The level and duration of Xe-Wee1 tyrosine phosphorylation is elevated significantly when the first cell cycle is elongated with nondegradable Mos. Importantly, we show that the tyrosine phosphorylation of Xe-Wee1 is required for the Mos-mediated M-phase delay. These findings indicate that Mos positively regulates Xe-Wee1 to generate the G2 phase in the first cell cycle and establish a direct link between the MAPK signal transduction pathway and Wee1 in vertebrates.
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