ArticleBritish journal of cancer1999
Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 141 citations in OpenAlex.
- Phase II trials of single-agent anti-VEGF therapy for patients with chronic lymphocytic leukemia.Leukemia & lymphoma · 2010Trial
- Article
- Histopathological Evaluation of Angiogenic Markers in Non-Hodgkin's Lymphoma.Journal of laboratory physicians · 2023Article
- Angiogenesis in Lymph Nodes Is a Critical Regulator of Immune Response and Lymphoma Growth.Frontiers in immunology · 2020Review
- Tumour-associated macrophages correlate with microvascular bed extension in colorectal cancer patients.Journal of cellular and molecular medicine · 2016Article
- Myeloid-derived suppressor cells in B cell malignancies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Review
- Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis.Frontiers in physiology · 2014Review
- The role of angiogenesis in human non-Hodgkin lymphomas.Neoplasia (New York, N.Y.) · 2013Review
- Critical signal transduction pathways in CLL.Advances in experimental medicine and biology · 2013Review
- Sorafenib, a multikinase inhibitor, is effective in vitro against non-Hodgkin lymphoma and synergizes with the mTOR inhibitor rapamycin.American journal of hematology · 2012Article
- Macrophage chemotactic protein-1 mRNA levels in non-Hodgkin lymphoma.Clinical and experimental medicine · 2010Article
- A double agent in cancer: deciphering macrophage roles in human tumors.Nature medicine · 2010Article
- Article
- The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma.Journal of leukocyte biology · 2010Review
- Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies.Journal of oncology · 2010Article
- Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma.Annals of oncology : official journal of the European Society for Medical Oncology · 2009Review
- Angiogenesis in primary central nervous system lymphoma (PCNSL).Journal of neuro-oncology · 2007Article
- Angiogenesis in nodal B cell lymphomas: a high throughput study.Journal of clinical pathology · 2007Article
- Macrophages promote angiogenesis in human breast tumour spheroids in vivo.British journal of cancer · 2006Article
- Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.Oncogene · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas (B-NHLs) were investigated for microvessel and macrophage counts using immunohistochemistry and morphometric analysis. Both counts were significantly higher in B-NHL. Moreover, when these were grouped into low-grade and high-grade lymphomas, according to the Kiel classification and Working Formulation (WF), statistically significant higher counts were found in the high-grade tumours. Immunohistochemistry and electron microscopy revealed a close spatial association between microvessels and macrophages. Overall, the results suggest that, in analogy to what has already been shown in solid tumours, angiogenesis occurring in B-NHLs increases with tumour progression, and that macrophages promote the induction of angiogenesis via the release of their angiogenic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.