ArticleBritish journal of cancer1999
p53 mutations in human cutaneous melanoma correlate with sun exposure but are not always involved in melanomagenesis.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Identification and characterization of BRAF⇔TP53 interactions in melanoma.Cell reports · 2026Article
- Evaluation of P53 immunostaining in patients with cutaneous melanoma.Biomedical reports · 2024Article
- Clinical feature-related single-base substitution sequence signatures identified with an unsupervised machine learning approach.BMC medical genomics · 2021Article
- Guided Antitumoural Drugs: (Imidazol-2-ylidene)(L)gold(I) Complexes Seeking Cellular Targets Controlled by the Nature of Ligand L.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Recognizing Pattern and Rule of Mutation Signatures Corresponding to Cancer Types.Frontiers in cell and developmental biology · 2021Article
- A new 4-(pyridinyl)-4H-benzo[g]chromene-5,10-dione ruthenium(II) complex inducing senescence in 518A2 melanoma cells.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2019Article
- cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy.Advances in protein chemistry and structural biology · 2019Review
- Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma.Oncogene · 2017Article
- Article
- Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.Journal of the National Cancer Institute · 2016Article
- Redox effects and cytotoxic profiles of MJ25 and auranofin towards malignant melanoma cells.Oncotarget · 2015Article
- Dominant effects of Δ40p53 on p53 function and melanoma cell fate.The Journal of investigative dermatology · 2014Article
- The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence.International journal of molecular sciences · 2013Review
- p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis.The Journal of experimental medicine · 2013Article
- The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis.International journal of molecular sciences · 2013Review
- Therapeutic efficacy by targeting correction of Notch1-induced aberrants in uveal tumors.PloS one · 2012Article
- P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation.BMC cancer · 2011Article
- Nevus senescence.ISRN dermatology · 2011Article
- High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.PloS one · 2011Article
- Somatic p16(INK4a) loss accelerates melanomagenesis.Oncogene · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In melanoma, the relationship between sun exposure and the origin of mutations in either the N-ras oncogene or the p53 tumour-suppressor gene is not as clear as in other types of skin cancer. We have previously shown that mutations in the N-ras gene occur more frequently in melanomas originating from sun-exposed body sites, indicating that these mutations are UV induced. To investigate whether sun exposure also affects p53 in melanoma, we analysed 81 melanoma specimens for mutations in the p53 gene. The mutation frequency is higher than thus far reported: 17 specimens (21%) harbour one or more p53 mutations. Strikingly, 17 out of 22 mutations in p53 are of the C:G to TA or CC:GG to TT:AA transitional type, strongly suggesting an aetiology involving UV exposure. Interestingly, the p53 mutation frequency in metastases was much lower than in primary tumours. In the case of metastases, a role for sun exposure was indicated by the finding that the mutations are present exclusively in skin metastases and not in internal metastases. Together with a relatively frequent occurrence of silent third-base pair mutations in primary melanomas, this indicates that the p53 mutations, at least in these tumours, have not contributed to melanomagenesis and may have originated after establishment of the primary tumour.
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