ArticleBritish journal of cancer1999
Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma.
Article in British journal of cancer, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 129 citations in OpenAlex.
- Breast cancer in the era of integrating "Omics" approaches.Oncogenesis · 2022Review
- Article
- PTEN Genetic and Epigenetic Alterations Define Distinct Subgroups in North Indian Breast Cancer PatientsAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival.Oncogene · 2018Article
- Recurrent copy number alterations in young women with breast cancer.Oncotarget · 2018Article
- Mouse Models of Breast Cancer Share Amplification and Deletion Events with Human Breast Cancer.Journal of mammary gland biology and neoplasia · 2017Article
- Regulation of Signal Transduction by DJ-1.Advances in experimental medicine and biology · 2017Article
- The association of PTEN hypermethylation and breast cancer: a meta-analysis.OncoTargets and therapy · 2016Article
- Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis.Nature cell biology · 2015Article
- Analysis of PTEN in two BRCA1 and BRCA2 wild-type familial breast cancer patients.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2015Article
- A novel deleterious PTEN mutation in a patient with early-onset bilateral breast cancer.BMC cancer · 2014Article
- Targeting the PI3-kinase/Akt/mTOR signaling pathway.Surgical oncology clinics of North America · 2013Review
- Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest.Human molecular genetics · 2013Article
- An intronic polymorphic deletion in the PTEN gene: implications for molecular diagnostic testing.British journal of cancer · 2013Article
- Clinical development of phosphatidylinositol 3-kinase inhibitors for cancer treatment.BMC medicine · 2012Review
- PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.The Journal of clinical endocrinology and metabolism · 2012Article
- Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies.Paediatric drugs · 2012Review
- PTEN gene: a model for genetic diseases in dermatology.TheScientificWorldJournal · 2012Article
- Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.BMC cancer · 2011Article
- Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody.Haematologica · 2010Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We examined a panel of sporadic breast carcinomas for loss of heterozygosity (LOH) in a 10-cM interval on chromosome 10 known to encompass the PTEN gene. We detected allele loss in 27 of 70 breast tumour DNAs. Fifteen of these showed loss limited to a subregion of the area studied. The most commonly deleted region was flanked by D10S215 and D10S541 and encompasses the PTEN locus. We used a combination of denaturing gradient gel electrophoresis and single-strand conformation polymorphism analyses to investigate the presence of PTEN mutations in tumours with LOH in this region. We did not detect mutations of PTEN in any of these tumours. Our data show that, in sporadic breast carcinoma, loss of heterozygosity of the PTEN locus is frequent, but mutation of PTEN is not. These results are consistent with loss of another unidentified tumour suppressor in this region in sporadic breast carcinoma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.