Trial reportThe Journal of physiology1999
Respiratory and cardiac modulation of single sympathetic vasoconstrictor and sudomotor neurones to human skin.
Trial report in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- Human sympathetic outflows to skin and muscle target organs fluctuate concordantly over a wide range of time-varying frequencies.The Journal of physiology · 2012Trial
- Firing properties of single vasoconstrictor neurones in human subjects with high levels of muscle sympathetic activity.The Journal of physiology · 1999Trial
- Human temperature regulation under heat stress in health, disease, and injury.Physiological reviews · 2022Review
- Effects of nasal high flow on nocturnal hypercapnia, sleep, and sympathovagal balance in patients with neuromuscular disorders.Sleep & breathing = Schlaf & Atmung · 2021Article
- Recording and quantifying sympathetic outflow to muscle and skin in humans: methods, caveats and challenges.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- β-Adrenergic receptor blockade does not modify non-thermal sweating during static exercise and following muscle ischemia in habitually trained individuals.European journal of applied physiology · 2018Article
- Random-amplitude sinusoidal linear acceleration causes greater vestibular modulation of skin sympathetic nerve activity than constant-amplitude acceleration.Experimental brain research · 2018Article
- Measuring and quantifying skin sympathetic nervous system activity in humans.Journal of neurophysiology · 2017Review
- Sensitivity to ischaemia of single sympathetic nerve fibres innervating the dorsum of the human foot.The Journal of physiology · 2017Article
- Blunted increases in skin sympathetic nerve activity are related to attenuated reflex vasodilation in aged human skin.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Article
- Central neural control of thermoregulation and brown adipose tissue.Autonomic neuroscience : basic & clinical · 2016Review
- Skin Sympathetic Nerve Activity is Modulated during Slow Sinusoidal Linear Displacements in Supine Humans.Frontiers in neuroscience · 2016Article
- Current Approaches to Quantifying Tonic and Reflex Autonomic Outflows Controlling Cardiovascular Function in Humans and Experimental Animals.Current hypertension reports · 2015Review
- Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction.The Journal of physiology · 2015Article
- Human cardiovascular responses to passive heat stress.Comprehensive Physiology · 2015Review
- Skin sympathetic nerve activity in humans during exposure to emotionally-charged images: sex differences.Frontiers in physiology · 2014Article
- Modulation of muscle sympathetic nerve activity by low-frequency physiological activation of the vestibular utricle in awake humans.Experimental brain research · 2013Article
- Cardiac-locked bursts of muscle sympathetic nerve activity are absent in familial dysautonomia.The Journal of physiology · 2013Article
- Evidence from bilateral recordings of sympathetic nerve activity for lateralisation of vestibular contributions to cardiovascular control.Experimental brain research · 2012Article
- Biphasic effects of tonic stimulation of muscle nociceptors on skin sympathetic nerve activity in human subjects.Experimental brain research · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The firing of single sympathetic neurones was recorded via tungsten microelectrodes in cutaneous fascicles of the peroneal nerve in awake humans. Studies were made of 17 vasoconstrictor neurones during cold-induced cutaneous vasoconstriction and eight sudomotor neurones during heat-induced sweating. Oligounitary recordings were obtained from 8 cutaneous vasconstrictor and 10 sudomotor sites. Skin blood flow was measured by laser Doppler flowmetry, and sweating by changes in skin electrical resistance within the innervation territory on the dorsum of the foot. 2. Perispike time histograms revealed respiratory modulation in 11 (65 %) vasoconstrictor and 4 (50 %) sudomotor neurones. After correcting for estimated conduction delays, the firing probability was higher in inspiration for both classes of neurone. Measured from the oligounitary recordings, the respiratory modulation indices were 67. 7 +/- 3.9 % for vasoconstrictor and 73.5 +/- 5.7 % for sudomotor neurones (means +/- s.e.m.). As previously found for sudomotor neurones, cardiac rhythmicity was expressed by 7 (41 %) vasoconstrictor neurones, 5 of which showed no significant coupling to respiration. Measured from the oligounitary records, the cardiac modulation of cutaneous vasoconstrictor activity was 58.6 +/- 4.9 %, compared with 74.4 +/- 6.4 % for sudomotor activity. 3. Both vasoconstrictor and sudomotor neurones displayed low average firing rates (0.53 and 0.62 Hz, respectively). The percentage of cardiac intervals in which units fired was 38 % and 35 %, respectively. Moreover, when considering only those cardiac intervals when a unit fired, vasoconstrictor and sudomotor neurones generated a single spike 66 % and 67 % of the time. Rarely were more than four spikes generated by a single neurone. 4. We conclude that human cutaneous vasoconstrictor and sudomotor neurones share several properties: both classes contain subpopulations that are modulated by respiration and/or the cardiac cycle. The data suggest that the intensity of a multi-unit burst of vasoconstrictor or sudomotor impulses is probably governed primarily by firing incidence and the recruitment of additional neurones, rather than by an increase in the number of spikes each unit contributes to a burst.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.