ArticleThe Journal of physiology1999
Inhibition by adenosine receptor agonists of synaptic transmission in rat periaqueductal grey neurons.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Lethal Interactions of neuronal networks in epilepsy mediated by both synaptic and volume transmission indicate approaches to prevention.Progress in neurobiology · 2025Review
- Review
- Paeoniflorin exerts analgesic and hypnotic effects via adenosine A1 receptors in a mouse neuropathic pain model.Psychopharmacology · 2016Article
- Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice.Journal of neurophysiology · 2015Article
- Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.The Journal of physiology · 2015Article
- Storm in a coffee cup: caffeine modifies brain activation to social signals of threat.Social cognitive and affective neuroscience · 2012Article
- Extracellular signal-regulated kinase 1/2 activation counteracts morphine tolerance in the periaqueductal gray of the rat.The Journal of pharmacology and experimental therapeutics · 2009Article
- Substance P drives endocannabinoid-mediated disinhibition in a midbrain descending analgesic pathway.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels.The Journal of physiology · 2007Article
- Adenosine A(1) receptor-mediated presynaptic inhibition at the calyx of Held of immature rats.The Journal of physiology · 2003Article
- Control of glutamatergic neurotransmission in the rat spinal dorsal horn by the nucleoside transporter ENT1.The Journal of physiology · 2003Article
- Presynaptic adenosine A1 receptors regulate retinohypothalamic neurotransmission in the hamster suprachiasmatic nucleus.Journal of neurobiology · 2002Article
- Adenosine A1 receptors reduce release from excitatory but not inhibitory synaptic inputs onto lateral horn neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Inhibition of calcium channels by opioid- and adenosine-receptor agonists in neurons of the nucleus accumbens.British journal of pharmacology · 2001Article
- Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The actions of selective adenosine A1 and A2 receptor agonists were examined on synaptic currents in periaqueductal grey (PAG) neurons using patch-clamp recordings in brain slices. 2. The A1 receptor agonist 2-chloro-N-cyclopentyladenosine (CCPA), but not the A2 agonist, 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamidoadenosine (CGS21680), inhibited both electrically evoked inhibitory (eIPSCs) and excitatory (eEPSCs) postsynaptic currents. The actions of CCPA were reversed by the A1 receptor antagonist 8-cyclopentyl-1, 3-dipropylxanthine (DPCPX). 3. In the absence or presence of forskolin, DPCPX had no effect on eIPSCs, suggesting that concentrations of tonically released adenosine are not sufficient to inhibit synaptic transmission in the PAG. 4. CCPA decreased the frequency of spontaneous miniature action potential-independent IPSCs (mIPSCs) but had no effect on their amplitude distributions. Inhibition persisted in nominally Ca2+-free, high Mg2+ solutions and in 4-aminopyridine. 5. The CCPA-induced decrease in mIPSC frequency was partially blocked by the non-selective protein kinase inhibitor staurosporine, the specific protein kinase A inhibitor 8-para-chlorophenylthioadenosine-3',5'-cyclic monophosphorothioate (Rp-8-CPT-cAMPS), and by 8-bromoadenosine cyclic 3',5' monophosphate (8-Br-cAMP). 6. These results suggest that A1 adenosine receptor agonists inhibit both GABAergic and glutamatergic synaptic transmission in the PAG. Inhibition of GABAergic transmission is mediated by presynaptic mechanisms that partly involve protein kinase A.
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