ArticleThe Journal of physiology1999
Kinetics of inactivation and restoration from inactivation of the L-type calcium current in human myotubes.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Voltage-gated Ca(2+) influx through L-type channels contributes to sarcoplasmic reticulum Ca(2+) loading in skeletal muscle.The Journal of physiology · 2015Article
- Ca(V)1.1: The atypical prototypical voltage-gated Ca²⁺ channel.Biochimica et biophysica acta · 2013Review
- A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels.The Journal of general physiology · 2010Article
- Rapid Ca2+ flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle.The Journal of physiology · 2009Article
- Low-frequency oscillations in the cerebellar cortex of the tottering mouse.Journal of neurophysiology · 2009Article
- Ca2+/CaM-dependent inactivation of the skeletal muscle L-type Ca2+ channel (Cav1.1).Pflugers Archiv : European journal of physiology · 2008Article
- Calcium currents and transients in co-cultured contracting normal and Duchenne muscular dystrophy human myotubes.The Journal of physiology · 2001Article
- Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes.The Journal of physiology · 2000Article
- Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel.The Journal of general physiology · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Inactivation and recovery kinetics of L-type calcium currents were measured in myotubes derived from satellite cells of human skeletal muscle using the whole cell patch clamp technique. 2. The time course of inactivation at potentials above the activation threshold was obtained from the decay of the current during 15 s depolarizing pulses. At subthreshold potentials, prepulses of different durations, followed by +20 mV test pulses, were used. The time course could be well described by single exponential functions of time. The time constant decreased from 17.8 +/- 7.5 s at -30 mV to 1.78 +/- 0.15 s at +50 mV. 3. Restoration from inactivation caused by 15 s depolarization to +20 mV was slowed by depolarization in the restoration interval. The time constant increased from 1.11 +/- 0.17 s at -90 mV to 7.57 +/- 2.54 s at -10 mV. 4. Restoration showed different kinetics depending on the duration of the conditioning depolarization. While the time constant was similar at restoration potentials of -90 and -50 mV after a 1 s conditioning prepulse, it increased with increasing prepulse duration at -50 mV and decreased at -90 mV. 5. The experiments showed that the rates of inactivation and restoration of the L-type calcium current in human myotubes were not identical when observed at the same potential. The results indicate the presence of more than one inactivated state and point to different voltage-dependent pathways for inactivation and restoration.
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