ArticleThe Journal of physiology1999
Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01365286 (Heart Rate Lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease), which is not on this map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heart Rate Lowering Efficacy and Respiratory Safety of Ivabradine in Patients With Obstructive Airway Disease
Who cites it
35 citing papers in PubMed, 87 citations in OpenAlex.
- Review
- Article
- Clarifying the composition of the ATP consumption factors required for maintaining ion homeostasis in mouse rod photoreceptors.Scientific reports · 2023Article
- Increasing cell culture density during a developmental window prevents fated rod precursors derailment toward hybrid rod-glia cells.Scientific reports · 2023Article
- Ivabradine in Cardiovascular Disease Management Revisited: a Review.Cardiovascular drugs and therapy · 2021Review
- Review
- Light responses of mammalian cones.Pflugers Archiv : European journal of physiology · 2021Review
- Loss of the K+ channel Kv2.1 greatly reduces outward dark current and causes ionic dysregulation and degeneration in rod photoreceptors.The Journal of general physiology · 2021Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- Shunt peaking in neural membranes.Journal of the Royal Society, Interface · 2016Article
- The rod-driven a-wave of the dark-adapted mammalian electroretinogram.Progress in retinal and eye research · 2014Review
- Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors.Stem cells (Dayton, Ohio) · 2013Article
- Functional analysis of missense mutations in Kv8.2 causing cone dystrophy with supernormal rod electroretinogram.The Journal of biological chemistry · 2012Article
- Charge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.The Journal of general physiology · 2012Article
- Gap-junctional coupling of mammalian rod photoreceptors and its effect on visual detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Modulation of rod photoreceptor output by HCN1 channels is essential for regular mesopic cone vision.Nature communications · 2011Article
- Article
- Ideal observer analysis of signal quality in retinal circuits.Progress in retinal and eye research · 2009Article
- Low-conductance HCN1 ion channels augment the frequency response of rod and cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The inward rectification induced by membrane hyperpolarization was studied in adult guinea-pig rods by the perforated-patch-clamp technique. 2. CsCl blocked the rectification observed in both voltage- and current-clamp recordings at voltages negative to -60 mV, while BaCl2 blocked the inward relaxation observed at voltages positive to -60 mV. The current activated at -90 mV had a low selectivity between sodium and potassium and reversed at -31.0 mV. 3. These observations suggest that two inward rectifiers are present in guinea-pig rods: a hyperpolarization-activated (Ih) and a hyperpolarization-deactivated (Ikx) current. The functional roles of Ih and Ikx were evaluated by stimulating rods with currents sinusoidally modulated in time. 4. Rods behave like bandpass amplifiers, with a peak amplification of 1.5 at about 2 Hz. For hyperpolarizations that mainly gate Ikx, amplification and phase shifts are fully accounted for by a rod membrane analogue model that includes an inductance. For hyperpolarizations that also gate Ih, a harmonic distortion became apparent. 5. Bandpass filtering and amplification of rod signals, associated with Ih and Ikx gating by membrane hyperpolarization, are strategically located to extend, beyond the limits imposed by the slow phototransductive cascade, the temporal resolution of signals spreading to the rod synapse.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.